CD86

CD86
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1I85、1NCN
识别号
别名	CD86；, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
外部ID	OMIM：601020 MGI：101773 HomoloGene：10443 GeneCards：CD86
相关疾病
	多发性硬化症
为以下药物的标靶
	阿巴西普
基因位置（人类）
染色体	3号染色体
终止	122,121,139 bp
基因位置（小鼠）
染色体	小鼠16号染色体
终止	36,486,443 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• coreceptor activity; • virus receptor activity; • 血浆蛋白结合; • signaling receptor binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • signaling receptor activity;
细胞组分	• integral component of membrane; • 细胞内膜结合细胞器; • 膜; • 细胞膜; • cell surface; • 外排体; • external side of plasma membrane;
生物学过程	• response to yeast; • 适应性免疫; • response to interferon-gamma; • immune system process; • cell-cell signaling; • T cell costimulation; • 老化; • myeloid dendritic cell differentiation; • cellular response to cytokine stimulus; • T cell proliferation involved in immune response; • toll-like receptor signaling pathway; • positive regulation of transcription, DNA-templated; • B cell activation; • response to lipopolysaccharide; • cellular response to metal ion; • negative regulation of T cell anergy; • defense response to virus; • 免疫反应; • positive regulation of T cell proliferation; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • 病毒进入; • viral process; • toll-like receptor 3 signaling pathway; • cellular response to lipopolysaccharide; • T细胞激活; • positive regulation of activated T cell proliferation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of protein kinase B signaling; • 信号转导; • cell surface receptor signaling pathway; • cytokine-mediated signaling pathway; • negative regulation of T cell proliferation;
	Sources:Amigo / QuickGO
直系同源
	942
	12524
	ENSG00000114013
	ENSMUSG00000022901
	P42081
	P42082
	NM_176892; NM_001206924; NM_001206925; NM_006889; NM_175862
	NM_019388
	NP_001193853; NP_001193854; NP_008820; NP_787058; NP_795711
	NP_062261
	维基数据
查看/编辑人类	查看/编辑小鼠

CD86（英语：Cluster of Differentiation 86，分化群86，也称为B7-2）是一个位于3号染色体的人类基因，属于免疫球蛋白超家族中的B7蛋白质家族^[7]，在树突状细胞、朗格汉斯细胞、巨噬细胞、B细胞（包括记忆B细胞）等抗原呈递细胞上表达^[8]。

事实速览 CD86, 已知的结构 ...

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CD86

参考文献

外部链接

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