CYP2D6

细胞色素 P450 2D6（cytochrome P450 2D6，CYP2D6）是一种由人类CYP2D6基因编码的酶。CYP2D6主要合成而显现于肝脏，并且也表现在中枢神经系统中，包括黑质。

Cytochrome P450, family 2, subfamily D, polypeptide 6
PDB基于2f9q的渲染图
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW
标识
代号	CYP2D6; CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1
扩展标识	遗传学：124030 鼠基因：1929474 同源基因：133550 GeneCards: CYP2D6 Gene
EC编号	1.14.14.1
基因本体论描述 分子功能 · monooxygenase activity · iron ion binding · drug binding · arachidonic acid epoxygenase activity · steroid hydroxylase activity · oxidoreductase activity · oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen · oxygen binding · heme binding · aromatase activity 细胞成分 · cytoplasm · mitochondrion · endoplasmic reticulum · endoplasmic reticulum membrane 生物过程 · xenobiotic metabolic process · steroid metabolic process · coumarin metabolic process · alkaloid metabolic process · alkaloid catabolic process · monoterpenoid metabolic process · drug metabolic process · arachidonic acid metabolic process · isoquinoline alkaloid metabolic process · drug catabolic process · exogenous drug catabolic process · small molecule metabolic process · heterocycle metabolic process · negative regulation of binding · oxidation-reduction process · oxidative demethylation · negative regulation of cellular organofluorine metabolic process Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	1565	13101
Ensembl	ENSG00000100197	ENSMUSG00000094806
UniProt	P10635	P24456
mRNA序列	NM_000106	NM_010005
蛋白序列	NP_000097	NP_034135
基因位置	Chr 22: 42.13 – 42.13 Mb	Chr 15: 82.4 – 82.41 Mb
PubMed查询	[1]	[2]
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CYP2D6是细胞色素P450混合功能氧化酶系统的成员之一，是人体中最重要的代谢酶之一。CYP2D6参与25%的临床药物的代谢和清除，过程主要是O-去甲基化。^[1]CYP2D6也参与多种内源性物质的代谢，如5-羟色胺和神经类固醇。^[1]