FOXP3

FOXP3（Forkhead box protein P3）基因，即叉头框P3基因，也称为scurfin蛋白，位于X染色体，属于FOX蛋白家族，是一种与免疫系统响应有关的转录因子^[6]。

FOXP3
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 3QRF、​4WK8
识别号
别名	FOXP3；, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
外部ID	OMIM：300292 MGI：1891436 HomoloGene：8516 GeneCards：FOXP3
相关疾病
IPEX综合征[1]
基因位置（人类） 染色体 X染色体[2] 基因座 Xp11.23 起始 49,250,438 bp[2] 终止 49,270,477 bp[2]
基因位置（小鼠） 染色体 小鼠X染色体[3] 基因座 X A1.1|X 3.41 cM 起始 7,439,883 bp[3] 终止 7,461,484 bp[3]
RNA表达模式
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基因本体 分子功能 • sequence-specific DNA binding • NF-kappaB binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • 血浆蛋白结合 • histone deacetylase binding • DNA结合转录因子活性 • NFAT protein binding • histone acetyltransferase binding • 金属离子结合 • DNA结合 • protein homodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding 细胞组分 • 细胞核 • 胞内 • 细胞质 • 核质 • 大分子复合体 生物学过程 • negative regulation of cell population proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription by RNA polymerase II • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • 肿瘤坏死因子产生的负调控 • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T细胞激活 • positive regulation of immature T cell proliferation in thymus • positive regulation of regulatory T cell differentiation • negative regulation of transcription by RNA polymerase II • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • 染色体重建 • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression • anatomical structure morphogenesis • regulation of Wnt signaling pathway • regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	50943	20371
Ensembl	ENSG00000049768	ENSMUSG00000039521
UniProt	Q9BZS1	Q99JB6
mRNA​序列	NM_001114377 ​NM_014009	NM_001199347 ​NM_001199348 ​NM_054039
蛋白序列	NP_001107849 ​NP_054728	NP_001186276 ​NP_001186277 ​NP_473380
基因位置​（UCSC）	Chr X: 49.25 – 49.27 Mb	Chr X: 7.44 – 7.46 Mb
PubMed​查找	[4]	[5]
维基数据
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