STAT6

信号转导及转录激活蛋白6（英语：Signal transducer and activator of transcription 6，STAT6）是一种由人类基因STAT6 编码的转录因子^[1][2]。

Signal transducer and activator of transcription 6, interleukin-4 induced 信号转导及转录激活蛋白6，白介素-4诱导
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1OJ5​
标识
代号	STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C
扩展标识	遗传学：601512 鼠基因：103034 同源基因：2373 ChEMBL: 5401 GeneCards: STAT6 Gene
基因本体论描述 分子功能 · RNA polymerase II core promoter sequence-specific DNA binding · sequence-specific DNA binding transcription factor activity · signal transducer activity · calcium ion binding · protein binding · identical protein binding 细胞成分 · nuclear chromatin · nucleus · nucleolus · cytoplasm · cytosol 生物过程 · negative regulation of transcription from RNA polymerase II promoter · T-helper 1 cell lineage commitment · negative regulation of type 2 immune response · transcription, DNA-dependent · regulation of transcription from RNA polymerase II promoter · signal transduction · cytokine-mediated signaling pathway · mammary gland epithelial cell proliferation · regulation of cell proliferation · positive regulation of transcription from RNA polymerase II promoter · positive regulation of isotype switching to IgE isotypes · mammary gland morphogenesis Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	6778	20852
Ensembl	ENSG00000166888	ENSMUSG00000002147
UniProt	P42226	P52633
mRNA序列	NM_001178078	NM_009284
蛋白序列	NP_001171549	NP_033310
基因位置	Chr 12: 57.49 – 57.53 Mb	Chr 10: 127.64 – 127.66 Mb
PubMed查询	[1]	[2]
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相互作用

STAT3能与下列蛋白质发生交互作用：

EP300,^[3]CREB-binding protein,^[3][4]NFKB1,^[5]Nuclear receptor coactivator 1,^[4][6]IRF4^[7]和SND1^[8]。

另见

• 白细胞介素-4