TLR2

Toll样受体2（英语：Toll-like receptor 2）是由人类基因 TLR2 编码的蛋白质^[5]，是一种膜蛋白质和受体，也被称为CD282（分化簇282，cluster of differentiation 282），是Toll样受体（TLR）家族的成员，在免疫系统中起到重要作用。

TLR2
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1FYW、​1FYX、​1O77、​2Z7X、​2Z80
识别号
别名	TLR2；, CD282, TIL4, toll like receptor 2
外部ID	OMIM：603028 MGI：1346060 HomoloGene：20695 GeneCards：TLR2
基因位置（人类） 染色体 4号染色体[1] 基因座 4q31.3 起始 153,684,070 bp[1] 终止 153,706,260 bp[1]
基因位置（小鼠） 染色体 小鼠3号染色体[2] 基因座 3|3 E3 起始 83,743,579 bp[2] 终止 83,749,074 bp[2]
RNA表达模式
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基因本体 分子功能 • pattern recognition receptor activity • lipopolysaccharide binding • Toll-like receptor binding • triacyl lipopeptide binding • 血浆蛋白结合 • peptidoglycan binding • protein heterodimerization activity • lipopolysaccharide immune receptor activity • transmembrane signaling receptor activity • lipopeptide binding 细胞组分 • 细胞质 • integral component of membrane • phagocytic vesicle membrane • 高尔基体 • 膜 • intrinsic component of plasma membrane • 细胞膜 • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • 脂筏模型 • cytoplasmic vesicle • cell projection • cell surface • cell body 生物学过程 • interleukin-10 production • positive regulation of interferon-beta production • defense response to Gram-positive bacterium • positive regulation of interleukin-18 production • positive regulation of toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • positive regulation of inflammatory response • cellular response to bacterial lipopeptide • positive regulation of interleukin-12 production • immune system process • detection of diacyl bacterial lipopeptide • cellular response to diacyl bacterial lipopeptide • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • MyD88-dependent toll-like receptor signaling pathway • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • positive regulation of Wnt signaling pathway • positive regulation of gene expression • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • 免疫反应 • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of chemokine production • 先天免疫系统 • inflammatory response • toll-like receptor TLR6:TLR2 signaling pathway • response to molecule of bacterial origin • 信号转导 • positive regulation of transcription by RNA polymerase II • 细胞凋亡 • response to lipopolysaccharide • response to progesterone • toll-like receptor signaling pathway • response to insulin • central nervous system myelin formation • nitric oxide metabolic process • response to fatty acid • leukotriene metabolic process • toll-like receptor 2 signaling pathway • positive regulation of oligodendrocyte differentiation • response to bacterial lipoprotein • negative regulation of cell population proliferation • response to toxic substance • response to hypoxia • positive regulation of interleukin-10 production • lipopolysaccharide-mediated signaling pathway • microglial cell activation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	7097	24088
Ensembl	ENSG00000137462	ENSMUSG00000027995
UniProt	O60603	Q9QUN7
mRNA​序列	​NM_003264 ​NM_001318787 ​NM_001318789 ​NM_001318790 ​NM_001318791 ​NM_001318793 ​NM_001318795 ​NM_001318796	NM_011905
蛋白序列	NP_001305716 ​NP_001305718 ​NP_001305719 ​NP_001305720 ​NP_001305722 ​NP_001305724 ​NP_001305725 ​NP_003255	NP_036035
基因位置​（UCSC）	Chr 4: 153.68 – 153.71 Mb	Chr 3: 83.74 – 83.75 Mb
PubMed​查找	[3]	[4]
维基数据
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