TRAF6

TRAF6是人类基因 TRAF6 编码的蛋白质，属于一种TNF受体相关因子（TRAF）。

TRAF6
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1LB4、​1LB5、​1LB6、​2ECI、​2JMD、​3HCS、​3HCT、​3HCU、​4Z8M
识别号
别名	TRAF6；, MGC:3310, RNF85, TNF receptor associated factor 6
外部ID	OMIM：602355 MGI：108072 HomoloGene：3395 GeneCards：TRAF6
基因位置（人类） 染色体 11号染色体[1] 基因座 11p12 起始 36,483,769 bp[1] 终止 36,510,272 bp[1]
基因位置（小鼠） 染色体 小鼠2号染色体[2] 基因座 2|2 E2 起始 101,508,774 bp[2] 终止 101,532,014 bp[2]
RNA表达模式
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基因本体 分子功能 • protein N-terminus binding • histone deacetylase binding • ubiquitin protein ligase activity • 金属离子结合 • mitogen-activated protein kinase kinase kinase binding • 锌离子结合 • 血浆蛋白结合 • thioesterase binding • ubiquitin conjugating enzyme binding • protein kinase binding • protein kinase B binding • 泛素蛋白转移酶活性 • 相同蛋白质结合 • 泛素蛋白连接酶结合 • 转移酶活性 • tumor necrosis factor receptor binding 细胞组分 • 细胞质 • 细胞质基质 • 脂滴 • 细胞质的核周区域 • cytoplasmic side of plasma membrane • 细胞核 • 细胞膜 • 细胞皮层 • endosome membrane • CD40 receptor complex • 大分子复合体 生物学过程 • positive regulation of transcription regulatory region DNA binding • response to interleukin-1 • toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • odontogenesis of dentin-containing tooth • animal organ morphogenesis • T-helper 1 type immune response • toll-like receptor 9 signaling pathway • regulation of apoptotic process • 成骨作用 • cytokine-mediated signaling pathway • osteoclast differentiation • positive regulation of osteoclast differentiation • stimulatory C-type lectin receptor signaling pathway • activation of NF-kappaB-inducing kinase activity • 骨质吸收 • JNK cascade • membrane protein intracellular domain proteolysis • protein ubiquitination • positive regulation of T cell proliferation • I-kappaB kinase/NF-kappaB signaling • protein autoubiquitination • immune system process • positive regulation of JUN kinase activity • positive regulation of DNA-binding transcription factor activity • protein polyubiquitination • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • positive regulation of lipopolysaccharide-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • positive regulation of T cell cytokine production • 免疫反应 • negative regulation of transcription, DNA-templated • 含有信号通路的核苷酸结合寡聚结构域 • positive regulation of protein ubiquitination • positive regulation of smooth muscle cell proliferation • antigen processing and presentation of exogenous peptide antigen via MHC class II • cell development • protein K63-linked ubiquitination • myeloid dendritic cell differentiation • MyD88-dependent toll-like receptor signaling pathway • neural tube closure • 骨的再建 • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to lipopolysaccharide • T cell receptor signaling pathway • activation of protein kinase activity • positive regulation of transcription by RNA polymerase II • 信号转导 • cellular response to DNA damage stimulus • protein deubiquitination • regulation of I-kappaB kinase/NF-kappaB signaling • interleukin-1-mediated signaling pathway • cellular response to cytokine stimulus • positive regulation of NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	7189	22034
Ensembl	ENSG00000175104	ENSMUSG00000027164
UniProt	Q9Y4K3	P70196
mRNA​序列	NM_145803 ​NM_004620	NM_009424 ​NM_001303273
蛋白序列	NP_004611 ​NP_665802	NP_001290202 ​NP_033450
基因位置​（UCSC）	Chr 11: 36.48 – 36.51 Mb	Chr 2: 101.51 – 101.53 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

蛋白质的相互作用

TRAF6蛋白与下列蛋白质进行互作：

• ASK1^[5][6][7]
• CD40^[8][9]
• FHL2^[10]
• HSPB2^[11]
• IKBKG^[12][13]
• IRAK1^{[14][15][16][17][18][19][20][21][22]}
• IRAK2^[15][16]
• TAB1^[23][24][25]
• MAP3K7IP2^{[12][22][23][24][26][27]}
• MAP3K7^{[7][22][23][24][25][26][28]}
• PPP4C^[29]
• RANK^{[30][31][32][33][34]}
• SDCBP^[14]
• SIGIRR^[35]
• Sequestosome 1^[36]
• TAX1BP1^[21]
• TNFAIP3^[37][38]
• TNFRSF13B^[39]
• UBE2N^[40]
• Ubiquitin C^{[13][27][29][41][42]}