白细胞介素-13

白细胞介素13
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1GA3、1IJZ、1IK0、3BPO、3G6D、3L5W、3L5X、3LB6、4I77、4PS4、5E4E
识别号
别名	IL13；, IL-13, P600, interleukin 13
外部ID	OMIM：147683 MGI：96541 HomoloGene：1649 GeneCards：IL13
相关疾病
	哮喘、霍奇金淋巴瘤、银屑病
基因位置（小鼠）
染色体	小鼠11号染色体
终止	53,525,529 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 血浆蛋白结合; • 细胞因子受体结合; • 细胞因子活性; • interleukin-13 receptor binding;
细胞组分	• 细胞质; • external side of plasma membrane; • 细胞外区域; • 细胞外空间;
生物学过程	• 内皮细胞凋亡过程的负调控; • negative regulation of complement-dependent cytotoxicity; • negative regulation of transforming growth factor beta production; • positive regulation of lung goblet cell differentiation; • response to mechanical stimulus; • response to nicotine; • positive regulation of release of sequestered calcium ion into cytosol; • microglial cell activation; • negative regulation of NAD(P)H oxidase activity; • cellular response to mechanical stimulus; • response to lipopolysaccharide; • negative regulation of lung ciliated cell differentiation; • positive regulation of ion transport; • 免疫反应; • positive regulation of protein secretion; • positive regulation of connective tissue growth factor production; • positive regulation of pancreatic stellate cell proliferation; • response to ethanol; • inflammatory response; • regulation of proton transport; • positive regulation of smooth muscle cell proliferation; • negative regulation of neuron death; • positive regulation of immunoglobulin production; • positive regulation of B cell proliferation; • positive regulation of macrophage activation; • positive regulation of mast cell degranulation; • cellular response to cytokine stimulus; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • positive regulation of gene expression; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	3596
	16163
	ENSG00000169194
	ENSMUSG00000020383
	P35225
	P20109
	NM_002188
	NM_008355
	NP_002179; NP_001341920; NP_001341921; NP_001341922
	NP_032381
	维基数据
查看/编辑人类	查看/编辑小鼠

白细胞介素-13（英语：Interleukin-13，缩写IL-13）是一种细胞因子，由人类基因 IL13 编码^[5]^[6]^[7]。IL-13结构上与白细胞介素-4（IL-4）非常相似，有25%的序列相似性^[8]，都能与由白介素-4受体α亚基（CD124）与白介素-13受体α1（CD213a1）组成的白介素-13受体结合。

事实速览 白细胞介素13, 已知的结构 ...

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白细胞介素-13

参考资料

外部链接

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