CD40

CD40
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1CZZ、1D00、1FLL、1LB6、3QD6、5DMJ、5IHL、5DMI
识别号
别名	CD40；, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
外部ID	OMIM：109535 MGI：88336 HomoloGene：954 GeneCards：CD40
相关疾病
	类风湿性关节炎、第三型高IgM症候群
基因位置（人类）
染色体	20号染色体
终止	46,129,863 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	164,914,868 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• antigen binding; • signal transducer activity; • 血浆蛋白结合; • tumor necrosis factor-activated receptor activity; • 酶结合; • 泛素蛋白连接酶结合; • protein domain specific binding; • signaling receptor activity;
细胞组分	• 细胞质; • integral component of membrane; • 细胞内膜结合细胞器; • 膜; • 细胞膜; • integral component of plasma membrane; • 细胞外区域; • cell surface; • CD40 receptor complex; • 外排体; • external side of plasma membrane; • 细胞外空间; • soma; • varicosity;
生物学过程	• positive regulation of protein phosphorylation; • positive regulation of MAP kinase activity; • positive regulation of interleukin-12 production; • Akt/PKB信号通路; • positive regulation of protein kinase C signaling; • immune system process; • cellular calcium ion homeostasis; • tumor necrosis factor-mediated signaling pathway; • immune response-regulating cell surface receptor signaling pathway; • platelet activation; • multicellular organism development; • B cell activation; • positive regulation of GTPase activity; • response to lipopolysaccharide; • B cell proliferation; • cellular response to mechanical stimulus; • positive regulation of endothelial cell apoptotic process; • regulation of cell population proliferation; • positive regulation of B cell proliferation; • positive regulation of NF-kappaB transcription factor activity; • defense response to virus; • 免疫反应; • regulation of immune response; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • apoptotic signaling pathway; • positive regulation of isotype switching to IgG isotypes; • cellular response to lipopolysaccharide; • positive regulation of transcription by RNA polymerase II; • defense response to protozoan; • response to bacterium; • response to nutrient levels; • response to cobalamin; • response to interferon-gamma; • cellular response to erythropoietin; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • response to peptide; • inflammatory response; • positive regulation of tyrosine phosphorylation of STAT protein; • positive regulation of blood vessel endothelial cell migration; • positive regulation of angiogenesis; • protein-containing complex assembly;
	Sources:Amigo / QuickGO
直系同源
	958
	21939
	ENSG00000101017
	ENSMUSG00000017652
	P25942
	P27512
NM_001250; NM_001302753; NM_152854; NM_001322421; NM_001322422;
	NM_001362758
	NM_011611; NM_170702; NM_170703; NM_170704
NP_001241; NP_001289682; NP_001309350; NP_001309351; NP_690593;
	NP_001349687
	NP_035741; NP_733803; NP_733804; NP_733805
	维基数据
查看/编辑人类	查看/编辑小鼠

分化簇40（Cluster of differentiation 40，简称CD40），是一种分布于抗原呈递细胞（APC）的协同刺激因子暨蛋白受体。CD40与辅助型T细胞上的CD154（英语：CD154）（CD40L（英语：CD40L））结合后，抗原呈递细胞会活化，并产生一系列下游反应^[6]。

事实速览 CD40, 已知的结构 ...

CD40缺失会造成第三型高IgM症候群（英语：Hyper-IgM syndrome type 3）（Hyper-IgM syndrome type 3）^[6]。

[6]

[1]

[2]

[3]

[4]

[5]

	相关	不相关
一般免疫	T细胞启动（priming）决定周边免疫球蛋白的浓度	周边淋巴器官及次级淋巴器官的淋巴球比例
体液免疫	胸腺依赖性抗原（Thymus dependent antigen）的初级抗体反应胸腺依赖性抗原（Thymus dependent antigen）的次级抗体反应及免疫球蛋白类型转换记忆B细胞及生发中心的发育	李斯特菌的廓清对抗多糖体的抗体反应
自体免疫	胶原蛋白引起的关节炎狼疮性肾炎实验性自体免疫脑炎（Experimental allergic encephalomyelitis）
胞杀作用及移植	急性或慢性移植物对抗宿主疾病（GVHD）异体移植的胞杀作用	抗病毒的胞杀反应抗癌细胞的胞杀反应
T细胞选汰	T细胞的胸腺选汰

CD40

结构及表达

功能

交互作用

临床应用

参考文献

外部链接

延伸阅读

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