MLL (基因)

髓样/淋巴样或混合世系白血病（三胸同源物，果蝇）
髓样/淋巴样或混合世系白血病（三胸同源物，果蝇）
	PDB rendering based on 2j2s.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2AGH, 2J2S, 2JYI, 2KKF, 2KU7, 2KYU, 2LXS, 2LXT, 2W5Y, 2W5Z, 3EG6, 3EMH, 3LQH, 3LQI, 3LQJ, 3P4F, 3U85, 3U88, 4ESG, 4GQ6
标识
代号	MLL; ALL-1; CXXC7; HRX; HTRX1; KMT2A; MLL/GAS7; MLL1A; TET1-MLL; TRX1; WDSTS
扩展标识	遗传学：159555 鼠基因：96995 同源基因：4338 ChEMBL: 1293299 GeneCards: MLL Gene
EC编号	2.1.1.43
基因本体论描述
分子功能	· AT DNA binding; · sequence-specific DNA binding transcription factor activity; · protein binding; · zinc ion binding; · histone methyltransferase activity (H3-K4 specific); · identical protein binding; · protein homodimerization activity; · transcription regulatory region DNA binding; · unmethylated CpG binding; · histone acetyl-lysine binding;
细胞成分	· nucleus; · histone methyltransferase complex; · MLL1 complex;
生物过程	· transcription from RNA polymerase II promoter; · protein complex assembly; · apoptotic process; · positive regulation of transporter activity; · embryonic hemopoiesis; · histone H4-K16 acetylation; · positive regulation of transcription, DNA-dependent; · positive regulation of transcription from RNA polymerase II promoter; · histone H3-K4 methylation; · histone H3-K4 trimethylation; · positive regulation of cellular response to drug;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	4297
Ensembl	ENSG00000118058
UniProt	Q03164
mRNA序列	NM_001197104
蛋白序列	NP_001184033
基因位置	Chr 11:; 118.31 – 118.4 Mb
PubMed查询	[1]
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