MLL (基因)

MLL
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2AGH、2J2S、2JYI、2KKF、2KU7、2KYU、2LXS、2LXT、2MTN、2W5Y、2W5Z、3EG6、3EMH、3LQI、3LQJ、3P4F、3U85、3U88、4ESG、4GQ6、4NW3、5F6L、5F5E
識別號
別名	KMT2A；, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, MLL-AF9, lysine methyltransferase 2A, Histone-lysine N-methyltransferase HRX, ALL1, HTRX
外部ID	MGI：96995 HomoloGene：4338 GeneCards：KMT2A
相關疾病
	Wiedemann-Steiner syndrome
基因位置（人類）
染色體	11號染色體
終止	118,526,832 bp
基因位置（小鼠）
染色體	小鼠9號染色體
終止	44,792,594 bp
RNA表達模式
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	• methyltransferase activity; • 轉移酶活性; • DNA結合; • protein homodimerization activity; • minor groove of adenine-thymine-rich DNA binding; • DNA結合轉錄因子活性; • 鋅離子結合; • chromatin binding; • 金屬離子結合; • core promoter sequence-specific DNA binding; • 血漿蛋白結合; • unmethylated CpG binding; • lysine-acetylated histone binding; • 相同蛋白質結合; • histone-lysine N-methyltransferase activity; • histone methyltransferase activity (H3-K4 specific); • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II cis-regulatory region sequence-specific DNA binding;
細胞組分	• 核質; • 細胞核; • histone methyltransferase complex; • 細胞質基質; • MLL1 complex;
生物學過程	• visual learning; • response to potassium ion; • regulation of transcription, DNA-templated; • 認知; • positive regulation of transporter activity; • positive regulation of cellular response to drug; • response to light stimulus; • rhythmic process; • regulation of short-term neuronal synaptic plasticity; • histone H3-K4 trimethylation; • membrane depolarization; • regulation of histone H3-K4 methylation; • regulation of histone H3-K9 acetylation; • transcription by RNA polymerase II; • post-embryonic development; • peptidyl-lysine monomethylation; • 脾的發生; • circadian regulation of gene expression; • regulation of histone H3-K14 acetylation; • transcription, DNA-templated; • regulation of histone H3-K27 acetylation; • positive regulation of transcription, DNA-templated; • DNA甲基化; • histone H3-K4 methylation; • 甲基化; • positive regulation of histone H3-K4 methylation; • 探究行為; • embryonic hemopoiesis; • histone H3-K4 dimethylation; • 基因調節; • homeostasis of number of cells within a tissue; • histone H4-K16 acetylation; • definitive hemopoiesis; • anterior/posterior pattern specification; • negative regulation of cell population proliferation; • 細胞凋亡; • regulation of megakaryocyte differentiation; • regulation of hematopoietic stem cell differentiation; • chromatin organization; • positive regulation of transcription by RNA polymerase II; • protein-containing complex assembly; • negative regulation of DNA methylation;
	Sources:Amigo / QuickGO
直系同源
	4297
	214162
	ENSG00000118058
	ENSMUSG00000002028
	Q03164
	P55200
	NM_001197104; NM_005933; NM_024891
	NM_001081049; NM_001357549
	NP_001184033; NP_005924
	NP_001344478
	維基數據
檢視/編輯人類	檢視/編輯小鼠