敵百蟲

敵百蟲（英語：trichlorfon，也稱為美曲磷酯，Metrifonate）是一種有機磷酸酯殺蟲劑和乙酰膽鹼酯酶抑制劑（英語：acetylcholinesterase inhibitor）^[3]，是一種前體藥物，可在非酶促情況下轉化為敵敵畏， 可用於治療血吸蟲病^[4]，但沒有商業化應用^[5]，也有提議用於治療阿茲海默症，但並未通過^[6]。

維基百科中的醫學內容僅供參考，並不能視作專業意見。如需獲取醫療幫助或意見，請諮詢專業人士。詳見醫學聲明。

敵百蟲

臨床資料
商品名（英語：Drug nomenclature）	Chlorophos (and many others)[1]Trichlorfon; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl) dimethylphosphonate; Agroforotox; Anthon; Chlorofos; Chloroftalm; Chlorophos; Chlorophthalm; Chloroxyphos; Combot; Dimethyl (trichlorohydroxyethyl)phosphonate; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; Dipterax; Dipterex; Dipterex 50; Diptevur; Ditrifon; Dylox; Dyrex; Dyvon; DEP; DEP (Pesticide); DETF; ENT 19,763; Flibol E; Fliegenteller; Forotox; Foschlor; Foschlor R; Foschlor R 50; Hypodermacid; Loisol; Masoten; Mazoten; Methyl Chlorophos; Metifonate; Metriphonate; Neguron; Neguvon; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; O,O-Dimethyl (2,2,2-trichlorohydroxyethyl)phosphonate; Phoschlor; Phoschlor R50; Polfoschlor; Ricifon; Ritsifon; Soldep; Sotipox; Trichlorphon; Trichlorphon FN; Tugon; Volfartol; Votexit; Wotexit; WEC 50; (1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester; (2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester; Bayer L 1359; Bilarcil; Bovinox; Briton; BAY 15922; Cekufon; Chlorophosciclosom; Clorofos; Danex; Dimethoxy-(2,2,2-trichloro-1-hydroxyethyl)phosphine oxide; Equino-Aid; Foschlorem; Khloroftalm; NCI-C54831; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphate; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphosaeure ester; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester; Proxol; Trichloorfon; Trichlorofon; Trichlorophon; Trinex; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; Bay-L 1359; Briten; Denkaphon; Dipterex WP 80; Ertefon; OMS 800; Zeltivar; Onefon; O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate;Trichlorfon; 1-Hydroxy-2,2,2-trichloroethylphosphonate-O,O-dimethyl ester; Phosphonic acid, P-(2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; Chlorak; Dimetox; Dioxaphos[2]
其他名稱	Trichlorphon
AHFS/Drugs.com	國際藥品名稱
ATC碼	P02BB01 (WHO) QP52AB01 QP53AF02
藥物動力學數據
生物半衰期	3 hours
識別資訊
IUPAC命名法 (RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
CAS號	52-68-6  Y
PubChem CID	5853
ChemSpider	5644 N
UNII	DBF2DG4G2K
KEGG	C07971 Y
ChEBI	CHEBI:6908 N
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID0021389
ECHA InfoCard	100.000.137
化學資訊
化學式	C4H8Cl3O4P
摩爾質量	257.436 g/mol
3D模型（JSmol（英語：JSmol））	交互式圖像
手性	Racemic mixture
SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC
InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3 N Key:NFACJZMKEDPNKN-UHFFFAOYSA-N N

參考文獻

1. Trichlorfon. Haz-Map. U.S. National Library of Medicine. August 2015 [2015-10-13]. （原始內容存檔於2015-09-20）.
2. Metrifonate. U.S. National Institute of Standards and Technology. [2016-09-04]. （原始內容存檔於2020-04-03）.
3. NLH - Neurological Conditions - Metrifonate for Alzheimer's disease. （原始內容存檔於2009-07-19）.
4. Monographs: Pharmaceutical substances: Metrifonate (Metrifonatum). The International Pharmacopoeia Fourth Edition. WHO. [2015-10-20]. （原始內容存檔於2016-06-03）. (dead link 31 January 2019)
5. Ross AG, Bartley PB, Sleigh AC, Olds GR, Li Y, Williams GM, McManus DP. Schistosomiasis. The New England Journal of Medicine. April 2002, 346 (16): 1212–20. PMID 11961151. doi:10.1056/NEJMra012396.
6. López-Arrieta JM, Schneider L. López-Arrieta J , 編. Metrifonate for Alzheimer's disease. The Cochrane Database of Systematic Reviews. April 2006, (2): CD003155. PMID 16625573. doi:10.1002/14651858.CD003155.pub3.