C-Myc維基百科,自由的 encyclopedia C-Myc或Myc是編碼轉錄因子的調節基因。這一基因編碼的蛋白在細胞核內被磷酸化,有多種功能:在細胞周期進程、細胞凋亡和細胞轉化中發揮作用。[5] Quick Facts c-Myc, 已知的結構 ...c-Myc已知的結構PDB直系同源搜尋: PDBe RCSB PDBID列表1A93、1EE4、1MV0、1NKP、2A93、2OR9、4Y7R識別號別名MYC;, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc外部IDOMIM:190080 MGI:97250 HomoloGene:31092 GeneCards:MYC 基因位置(人類)染色體8號染色體[1]基因座8q24.21起始127,735,434 bp[1]終止127,742,951 bp[1]基因位置(小鼠)染色體小鼠15號染色體[2]基因座15 D1|15 26.19 cM起始61,857,240 bp[2]終止61,862,223 bp[2]基因本體分子功能• DNA結合• protein dimerization activity• DNA結合轉錄因子活性• DNA-binding transcription activator activity, RNA polymerase II-specific• 轉錄因子結合• RNA polymerase II cis-regulatory region sequence-specific DNA binding• E-box binding• 血漿蛋白結合• 大分子複合物結合• DNA-binding transcription factor activity, RNA polymerase II-specific• DNA結合轉錄阻遏物活性,RNA聚合酶II特異性細胞組分• 核質• 核仁• 細胞核• 大分子複合體生物學過程• Notch信號通路• 染色體重建• negative regulation of monocyte differentiation• positive regulation of metanephric cap mesenchymal cell proliferation• regulation of transcription, DNA-templated• regulation of telomere maintenance• positive regulation of epithelial cell proliferation• positive regulation of fibroblast proliferation• cellular response to UV• oxygen transport• negative regulation of apoptotic process• negative regulation of transcription by RNA polymerase II• chromosome organization• MAPK cascade• cellular response to DNA damage stimulus• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process• branching involved in ureteric bud morphogenesis• negative regulation of cell division• fibroblast apoptotic process• positive regulation of mesenchymal cell proliferation• positive regulation of response to DNA damage stimulus• positive regulation of cell population proliferation• positive regulation of DNA biosynthetic process• 基因調節• canonical Wnt signaling pathway• negative regulation of stress-activated MAPK cascade• energy reserve metabolic process• response to growth factor• response to gamma radiation• negative regulation of fibroblast proliferation• positive regulation of transcription by RNA polymerase II• cellular iron ion homeostasis• beta-catenin-TCF complex assembly• transcription, DNA-templated• transcription by RNA polymerase II• regulation of transcription by RNA polymerase II• protein deubiquitination• positive regulation of transcription, DNA-templated• positive regulation of telomerase activity• positive regulation of gene expression• protein-DNA complex disassembly• ERK1 and ERK2 cascade• cellular response to hypoxia• G1/S transition of mitotic cell cycle• cytokine-mediated signaling pathway• positive regulation of DNA methylationSources:Amigo / QuickGO直系同源物種人類小鼠Entrez460917869EnsemblENSG00000136997ENSMUSG00000022346UniProtP01106P01108mRNA序列NM_002467NM_001354870NM_001177352NM_001177353NM_001177354NM_010849蛋白序列NP_002458NP_001341799NP_001170823NP_001170824NP_001170825NP_034979基因位置(UCSC)Chr 8: 127.74 – 127.74 MbChr 15: 61.86 – 61.86 MbPubMed查找[3][4]維基數據檢視/編輯人類檢視/編輯小鼠Close
C-Myc或Myc是編碼轉錄因子的調節基因。這一基因編碼的蛋白在細胞核內被磷酸化,有多種功能:在細胞周期進程、細胞凋亡和細胞轉化中發揮作用。[5] Quick Facts c-Myc, 已知的結構 ...c-Myc已知的結構PDB直系同源搜尋: PDBe RCSB PDBID列表1A93、1EE4、1MV0、1NKP、2A93、2OR9、4Y7R識別號別名MYC;, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc外部IDOMIM:190080 MGI:97250 HomoloGene:31092 GeneCards:MYC 基因位置(人類)染色體8號染色體[1]基因座8q24.21起始127,735,434 bp[1]終止127,742,951 bp[1]基因位置(小鼠)染色體小鼠15號染色體[2]基因座15 D1|15 26.19 cM起始61,857,240 bp[2]終止61,862,223 bp[2]基因本體分子功能• DNA結合• protein dimerization activity• DNA結合轉錄因子活性• DNA-binding transcription activator activity, RNA polymerase II-specific• 轉錄因子結合• RNA polymerase II cis-regulatory region sequence-specific DNA binding• E-box binding• 血漿蛋白結合• 大分子複合物結合• DNA-binding transcription factor activity, RNA polymerase II-specific• DNA結合轉錄阻遏物活性,RNA聚合酶II特異性細胞組分• 核質• 核仁• 細胞核• 大分子複合體生物學過程• Notch信號通路• 染色體重建• negative regulation of monocyte differentiation• positive regulation of metanephric cap mesenchymal cell proliferation• regulation of transcription, DNA-templated• regulation of telomere maintenance• positive regulation of epithelial cell proliferation• positive regulation of fibroblast proliferation• cellular response to UV• oxygen transport• negative regulation of apoptotic process• negative regulation of transcription by RNA polymerase II• chromosome organization• MAPK cascade• cellular response to DNA damage stimulus• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process• branching involved in ureteric bud morphogenesis• negative regulation of cell division• fibroblast apoptotic process• positive regulation of mesenchymal cell proliferation• positive regulation of response to DNA damage stimulus• positive regulation of cell population proliferation• positive regulation of DNA biosynthetic process• 基因調節• canonical Wnt signaling pathway• negative regulation of stress-activated MAPK cascade• energy reserve metabolic process• response to growth factor• response to gamma radiation• negative regulation of fibroblast proliferation• positive regulation of transcription by RNA polymerase II• cellular iron ion homeostasis• beta-catenin-TCF complex assembly• transcription, DNA-templated• transcription by RNA polymerase II• regulation of transcription by RNA polymerase II• protein deubiquitination• positive regulation of transcription, DNA-templated• positive regulation of telomerase activity• positive regulation of gene expression• protein-DNA complex disassembly• ERK1 and ERK2 cascade• cellular response to hypoxia• G1/S transition of mitotic cell cycle• cytokine-mediated signaling pathway• positive regulation of DNA methylationSources:Amigo / QuickGO直系同源物種人類小鼠Entrez460917869EnsemblENSG00000136997ENSMUSG00000022346UniProtP01106P01108mRNA序列NM_002467NM_001354870NM_001177352NM_001177353NM_001177354NM_010849蛋白序列NP_002458NP_001341799NP_001170823NP_001170824NP_001170825NP_034979基因位置(UCSC)Chr 8: 127.74 – 127.74 MbChr 15: 61.86 – 61.86 MbPubMed查找[3][4]維基數據檢視/編輯人類檢視/編輯小鼠Close