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二氢乳清酸酶

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carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase (fragment) dimer, Human
识别
符号 CAD
Entrez 790
HUGO 1424
OMIM 114010
RefSeq NM_004341
UniProt P27708
其他资料
EC编号 3.5.2.3
基因座 2 p22-p21

二氢乳清酸酶(英语:DihydroorotaseEC 3.5.2.3)也称为氨甲酰天冬氨酸脱水酶(英语:carbamoylaspartic dehydrase)又叫作二氢乳清酸酶水解酶(英语:dihydroorotate hydrolase)催化嘧啶生物合成过程中,氨甲酰天冬氨酸脱去一个水分子并环化为4,5-二氢乳清酸的反应[1][2]。在动物中,二氢乳清酸酶(D)和氨甲酰合成酶(C)、天冬氨酸转氨甲酰酶A)融合成了一个多酶复合体CAD

另见

  • 嘧啶代谢

参考文献

  1. ^ Cooper C, Wilson DW. Biosynthesis of pyrimidines. Fed. Proc. 1954, 13: 194–194. 
  2. ^ Lieberman I, Kornberg A. Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin (PDF). The Journal of Biological Chemistry. April 1954, 207 (2): 911–24. PMID 13163076. 

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二氢乳清酸酶
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