氨基酚AcetaminophenParacetamol、简称:APAP),又称胺酚[11]扑热息痛,是一种用疼痛发烧[12][13]。可用于缓度至中度的疼痛[12],本品对于孩童的退效果仍未有定性结论[14][15]。本品常感冒使用[12]。也可类药合用以解重度疼痛、癌痛,或术后疼痛[16]。本品可口服、肛,或静脉注射给药[12][17]。效用可持2至4小[17]

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Quick facts: 临床资料, 读音, 商品名(英语:Drug nomenclature), 其他名称, AH...
对乙酰氨基酚
读音Paracetamol: /ˌpærəˈsitəmɒl/
Acetaminophen: i/əˌstəˈmɪnəfɪn/
商品名英语Drug nomenclature泰诺及其他[1][2]
其他名N-acetyl-para-aminophenol (APAP)
AHFS英语American Society of Health-System Pharmacists/Drugs.comMonograph
MedlinePlusa681004
核准状况
怀孕分
  • : A
  • 测试但似乎是安全的
给药途径口服给药颊内给药英语Buccal administration英语rectal administration静脉注射
ATC
法律规范状态
法律规范
  • : S4 (Rx), OTC, 和计划外(unscheduled)
  • : 一般销售列表 (GSL, OTC)
  • : OTC
  • : 乙类非处方药
数据
生物利用度63–89%[3]:73
蛋白合率10–25%[4]
药物代谢大部分[5]
谢产APAP gluc英语Glucuronide]]、APAP sulfate、APAP GSH、APAP cysNAPQI英语NAPQI]][6]
效起始时间英语Onset of action给药而定:
口服:37 分[7]
颊内英语Buccal administration:15分[7]
静脉注射:8分[7]
生物半衰期1–4 小[5]
排泄途尿(85–90%)[5]
识别
CAS号103-90-2  
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB配ID
CompTox Dashboard (EPA)
ECHA InfoCard100.002.870
化学
化学式C8H9NO2
摩尔质量151.163 g/mol
3D model (JSmol)
密度1.263 g/cm3
熔点169 °C(336 °F) [8][9]
沸点420 °C(788 °F)
水溶性7.21 g/kg (0 °C)[10]

8.21 g/kg (5 °C)[10]
9.44 g/kg (10 °C)[10]
10.97 g/kg (15 °C)[10]
12.78 g/kg (20 °C)[10]

~14 mg/mL (20 °C)
  (verify)
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虽然按推荐剂量服用对乙酰氨基酚很安全[18],但仍可能现严疹等副作用。量可能肝衰竭[12]妊娠哺乳药显安全[12]。有肝疾病的患者仍可使用本品,但服用量必须减[19]。本品属于轻止痛[17],但并无活性,而通常不被归为固醇抗,它主要通抑制分布在COX-2英语COX-2]],以前列腺素的生成,解疼痛,但由COX-2在周边组织少,因此作用微弱[20],且其作用制迄今未明[21]

对乙酰氨基酚最早1877年发现[22]洲最常用的退及止痛[23]。本品列名世界卫生组织基本药物标准清单之中,卫体系必备药物之一[24]。本品属于通用名药物[25],每发展中国家的批发价0.01美元[26],在美样剂需0.04美金[27]

商品名必理痛香港[28]普拿疼[29]必理通大陆[30]斑纳杜[31]泰诺

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