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桥粒黏蛋白

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桥粒黏蛋白
鉴定
标志DSG
InterPro英语InterProIPR009123
膜蛋白数据库英语Membranome243

桥粒黏蛋白(英语:desmoglein)是由蛋白质DSG1、DSG2、DSG3和DSG4组成的桥粒钙粘蛋白家族。它们在连接细胞的桥粒的形成中发挥作用。[1]

病理学

桥粒黏蛋白靶向自体免疫性疾病天疱疮。[2][3][4]

桥粒黏蛋白是一种钙粘蛋白,这种跨膜蛋白可与其他钙粘蛋白结合,形成一种被称为细胞间桥粒的连接。这些桥粒黏蛋白将细胞结合在一起,但是当机体开始产生针对桥粒黏蛋白的抗体时,连接处会分解,从而导致水泡囊泡的形成。[5][6]

参考资料

  1. ^ Kline, Crystal F.; Mohler, Peter J., Bennett, Vann , 编, Chapter Four - Evolving Form to Fit Function: Cardiomyocyte Intercalated Disc and Transverse-Tubule Membranes, Current Topics in Membranes, Functional Organization of Vertebrate Plasma Membrane (Academic Press), 2013-01-01, 72: 121–158 [2020-10-23], doi:10.1016/b978-0-12-417027-8.00004-0 (英语) 
  2. ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D. Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction. J. Clin. Invest. November 2005, 115 (11): 3157–65. PMC 1242188. PMID 16211092. doi:10.1172/JCI23475. 
  3. ^ Kljuic A, Bazzi H, Sundberg JP, 等. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell. April 2003, 113 (2): 249–60. PMID 12705872. doi:10.1016/S0092-8674(03)00273-3可免费使用. 
  4. ^ Müller R, Heber B, Hashimoto T, 等. Autoantibodies against desmocollins in European patients with pemphigus. Clin. Exp. Dermatol. May 2009, 34 (8): 898–903. PMID 19456767. S2CID 774308. doi:10.1111/j.1365-2230.2009.03241.x. 
  5. ^ A Clinician's Guide to Pemphigus Vulgarishttp://www.springer.com/gp/book/9783319677583
  6. ^ Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. Philadelphia: Elsevier Saunders; 2012

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桥粒黏蛋白
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