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烟酰胺腺嘌呤二核苷酸磷酸

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烟酰胺腺嘌呤二核苷酸磷酸
识别
CAS号 53-59-8  ✓
PubChem 5884
ChemSpider 5674
InChI
InChIKey XJLXINKUBYWONI-NNYOXOHSBN
ChEBI 44409
MeSH NADP
性质
化学式 C21H29N7O17P3
摩尔质量 744.413 g·mol⁻¹
若非注明,所有数据均出自一般条件(25 ℃,100 kPa)下。

xiān胺腺嘌呤piàolìng二核gān酸磷酸(简称:辅酶Ⅱ,英语:nicotinamide adenine dinucleotide phosphate, NADP+),曾被称为三磷酸吡啶bǐdìng核苷酸triphosphopyridine nucleotide,缩写为TPN),是一种极为重要的核苷酸辅酶,它是烟酰胺腺嘌呤二核苷酸(NAD+)中与腺嘌呤相连的核糖环系2'-位的磷酸化衍生物,参与多种合成代谢反应,如脂类、脂肪酸和核苷酸的合成。这些反应中需要NADP+的还原形式NADPH作为还原剂、氢负供体。

植物叶绿体中,光合作用光反应电子链的最后一步以NADP+为原料,经铁氧还蛋白-NADP+还原酶的催化而产生NADPH。产生的NADPH接下来在碳反应中被用于二氧化碳的同化。

对于动物来说,磷酸戊糖途径的氧化相是细胞中NADPH的主要来源,由它可以产生60%的所需NADPH。

合成

由NADP+激酶催化下接受ATP的γ-磷酸基团而得到。

使用 NADP(H)作为辅酶之酶

  • 肾上腺皮质铁氧还蛋白还原酶英语Adrenodoxin reductase,又称为肾上腺髓质素还原酶


这种酶存在于大多数生物体中。[1]它将两个电子从NADPH转移到FAD。 在脊椎动物体中,它也是合成类固醇激素的线粒体P450系统链中的第一个酶。[2]

相关条目

参考资料

  1. ^ Hanukoglu I. Conservation of the Enzyme-Coenzyme Interfaces in FAD and NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme. Journal of Molecular Evolution. 2017, 85 (5): 205–218. PMID 29177972. doi:10.1007/s00239-017-9821-9. 
  2. ^ Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. Dec 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5. 
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烟酰胺腺嘌呤二核苷酸磷酸
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