细胞因子受体(英语:Cytokine receptor)是指能与细胞因子相结合的受体[1]

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I型和II型细胞因子受体介导的JAK-STAT信号通路步骤
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信号转导:细胞因子受体位于左侧中间

近年来,和细胞因子相比,细胞因子受体获得了更多的关注,部分原因是其引人注目的特性,还有部分原因是细胞因子受体的缺失与免疫缺陷的状态直接相关。

分类

比较

More information 类型, 例子 ...
类型 例子 结构 机制
I型细胞因子受体
  • Type 1 interleukin receptors
  • Erythropoietin receptor
  • GM-CSF receptor
  • G-CSF receptor
  • growth hormone receptor
  • prolactin receptor
  • Oncostatin M receptor
  • Leukemia inhibitory factor receptor
Certain conserved motifs in their extracellular amino-acid domain.与酪氨酸激酶中的JAK家族相连 JAK phosphorylate and activate downstream proteins involved in their signal transduction pathways
II型细胞因子受体
  • Type II interleukin receptors
  • interferon-alpha/beta receptor
  • interferon-gamma receptor
免疫球蛋白超家族英语immunoglobulin superfamily中的一些成员
  • Interleukin-1 receptor
  • CSF1
  • C-kit receptor
  • Interleukin-18 receptor
Share structural homology with immunoglobulins (antibodies), cell adhesion molecules, and even some cytokines.
肿瘤坏死因子受体家族英语Tumor necrosis factor receptor 共同的富半胱氨酸胞外结构域,结合配体
趋化因子受体
  • Interleukin-8 receptor
  • CCR1
  • CXCR4
  • MCAF receptor
  • NAP-2 receptor
七个跨膜螺旋 G蛋白偶联
TGF beta receptors
  • TGF beta receptor 1
  • TGF beta receptor 2
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可溶性

细胞因子受体既有与膜结合的又有可溶的,“可溶性细胞因子”非常常见受体,对细胞因子的有着重要的调控作用。

另见

参考文献

外部链接

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