15号染色体是人类23对染色体中的一对，正常人拥有2条15号染色体。15号染色体缠绕了约1亿100万碱基对（构筑DNA的材料），并包含了人类细胞中约3%至3.5%的DNA。每条染色体上的基因识别是遗传研究活跃的领域。因为研究人员使用不同的方法来进行对于每一条染色体基因数目的预测，而基因数目的估计会有所变化。15号染色体的基因数目有可能介于700个至900个[2]。
Quick Facts 15号染色体, 特征 ...
Close
Quick Facts 15号染色体 ...
| 15号染色体
|
|
|
| 物种
|
Homo sapiens
|
| 基因数量
|
1,428
|
Close
15号染色体基因组成有CAPN3、CHP、FAH、FBN1、HEXA、IVD、MCPH4、OCA2、RAD51、STRC、UBE3A、PML、SLC24A5等等，详细基因组成的介绍请参见英文版本的维基百科。
- Bittel DC, Butler MG. Prader-Willi syndrome: clinical genetics, cytogenetics and molecular biology. Expert Rev Mol Med. 2005, 7 (14): 1–20. PMID 16038620. doi:10.1017/S1462399405009531.（英文）
- Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. J Med Genet. 2003, 40 (8): 568–574. PMC 1735542
. PMID 12920063. doi:10.1136/jmg.40.8.568.（英文）
- Bittel DC, Kibiryeva N, Talebizadeh Z, Driscoll DJ, Butler MG. Microarray analysis of gene/transcript expression in Angelman syndrome: deletion versus UPD. Genomics. 2005, 85 (1): 85–91. PMID 15607424. doi:10.1016/j.ygeno.2004.10.010.（英文）
- Borgatti R, Piccinelli P, Passoni D, Dalpra L, Miozzo M, Micheli R, Gagliardi C, Balottin U. Relationship between clinical and genetic features in "inverted duplicated chromosome 15" patients. Pediatr Neurol. 2001, 24 (2): 111–116. PMID 11275459. doi:10.1016/S0887-8994(00)00244-7.（英文）
- Butler MG, Bittel DC, Kibiryeva N, Talebizadeh Z, Thompson T. Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy. Pediatrics. 2004, 113 (3 Pt 1): 565–573. PMID 14993551. doi:10.1542/peds.113.3.565.
- Cassidy SB, Dykens E, Williams CA. Prader-Willi and Angelman syndromes: sister imprinted disorders. Am J Med Genet. 2000, 97 (2): 136–146. PMID 11180221. doi:10.1002/1096-8628(200022)97:2<136::AID-AJMG5>3.0.CO;2-V.（英文）
- Clayton-Smith J, Laan L. Angelman syndrome: a review of the clinical and genetic aspects. J Med Genet. 2003, 40 (2): 87–95. PMC 1735357 . PMID 12566516. doi:10.1136/jmg.40.2.87.（英文）
- Gilbert F. Disease genes and chromosomes: disease maps of the human genome. Chromosome 15. Genet Test. 1999, 3 (3): 309–322. PMID 10495933. doi:10.1089/109065799316653.（英文）
- Lee S, Wevrick R. Identification of novel imprinted transcripts in the Prader-Willi syndrome and Angelman syndrome deletion region: further evidence for regional imprinting control. Am J Hum Genet. 2000, 66 (3): 848–858. PMC 1288168 . PMID 10712201. doi:10.1086/302817.（英文）
- Rineer S, Finucane B, Simon EW. Autistic symptoms among children and young adults with isodicentric chromosome 15. Am J Med Genet. 1998, 81 (5): 428–433. PMID 9754629. doi:10.1002/(SICI)1096-8628(19980907)81:5<428::AID-AJMG12>3.0.CO;2-E.（英文）
- Zollino M, Tiziano F, Di Stefano C, Neri G. Partial duplication of the long arm of chromosome 15: confirmation of a causative role in craniosynostosis and definition of a 15q25-qter trisomy syndrome. Am J Med Genet. 1999, 87 (5): 391–394. PMID 10594876. doi:10.1002/(SICI)1096-8628(19991222)87:5<391::AID-AJMG4>3.0.CO;2-O.（英文）
