23S rRNA是一个长为2904nt(在大肠杆菌中)的细菌核糖体大亚基(50S亚基)组分。核糖体的肽基转移酶活性中心就位于此rRNA的第五结构域(domain V),而此结构域也是许多抑制转录的抗生素的常见作用位点。这一类抗生素包括著名的氯霉素,通过抑制肽键形成来发挥作用。利奈唑胺和奎奴普汀/达福普汀也能结合于23S rRNA。
另见
- 23S methyl RNA motif
参考文献
外部链接
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