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GNA

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GNA全名Glycerol nucleic acid,中文直译甘油核酸。是一种与DNARNA相似的化学物质,但组成物有所不同。并不存在任何目前已知的自然界生物体内。

GNA的骨架是由许多重复的甘油(DNA与RNA为五碳糖)经由磷酸酯键的连结所组成。虽然甘油分子只有3个原子,但GNA仍然可比表现出沃森-克里克碱基配对(A对T;G对C),而且比起DNA与RNA,GNA的碱基配对更为稳定,需要较高的融解温度(Tm)才能解开。

参考文献

  • Zhang Lilu, Peritz Adam, Meggers Eric. A simple glycol nucleic acid (PDF). J Am Chem Soc. 2005, 127 (12): 4174–5. PMID 15783191. (原始内容 (PDF)存档于2007-01-06). 
  • Seita, Tooru; Yamauchi, Kiyoshi; Kinoshita, Masayoshi; Imoto, Minoru. Condensation polymerization of nucleotide analogues. Die Makromolekulare Chemie (1972), 154:255-261.
  • Ueda, Nasuo; Kawabata, Toshio; Takemoto, Kiichi. Synthesis of N-(2,3-dihydroxypropyl) derivatives of nucleic bases. Journal of Heterocyclic Chemistry (1971), 8(5), 827-9.
  • Acevedo, Oscar L.; Andrews, Robert S. Synthesis of propane-2,3-diol combinatorial monomers. Tetrahedron Letters (1996), 37(23), 3931-3934.
  • Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Synthesis of acyclic oligonucleotides as antiviral and antiinflammatory agents and inhibitors of phospholipase A2. PCT Int. Appl. (1995), 126 pp. WO 9518820 A1 19950713 CAN 124:30276 AN 1995:982328
  • Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Preparation of ethylene glycol phosphate linked oligodeoxyribonucleotides as phospholipase A2 inhibitors. U.S. (1999), 39 pp., Cont.-in-part of U.S. Ser. No. 179,970. CODEN: USXXAM US 5886177 A 19990323 CAN 130:237811 AN 1999:205354

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