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HaCaT细胞

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HaCaT是一种来自于成年人类的永生化角质形成细胞的细胞系[1][2]。HaCaT细胞因具有良好的体外分化和增殖能力而被利用于多项研究[3][4],作为可重现的模型来表征人类角质形成细胞,并且解决培养寿命短和细胞系间出现变异等的问题。HaCaT细胞可以表征多个过程,例如将它们用作皮肤中维生素D3进行代谢模型系统[5]

参考资料

  1. ^ Boukamp, P; Petrussevska, RT; Breitkreutz, D; Hornung, J; Markham, A; Fusenig, NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.. The Journal of cell biology. 1988-03, 106 (3): 761–71 [2019-11-28]. PMID 2450098. doi:10.1083/jcb.106.3.761. 
  2. ^ Olschläger, V; Schrader, A; Hockertz, S. Comparison of primary human fibroblasts and keratinocytes with immortalized cell lines regarding their sensitivity to sodium dodecyl sulfate in a neutral red uptake cytotoxicity assay.. Arzneimittel-Forschung. 2009, 59 (3): 146–52 [2019-11-28]. PMID 19402346. doi:10.1055/s-0031-1296378. 
  3. ^ Schoop, VM; Mirancea, N; Fusenig, NE. Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts.. The Journal of investigative dermatology. 1999-03, 112 (3): 343–53 [2019-11-28]. PMID 10084313. doi:10.1046/j.1523-1747.1999.00524.x. 
  4. ^ Schürer, N; Köhne, A; Schliep, V; Barlag, K; Goerz, G. Lipid composition and synthesis of HaCaT cells, an immortalized human keratinocyte line, in comparison with normal human adult keratinocytes.. Experimental dermatology. 1993-08, 2 (4): 179–85 [2019-11-28]. PMID 8162337. doi:10.1111/j.1600-0625.1993.tb00030.x. 
  5. ^ Lehmann, B. HaCaT cell line as a model system for vitamin D3 metabolism in human skin.. The Journal of investigative dermatology. 1997-01, 108 (1): 78–82 [2019-11-28]. PMID 8980292. doi:10.1111/1523-1747.ep12285640. 

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HaCaT细胞
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