模板:PBB/3952维基媒体模板 / 维基百科,自由的 encyclopedia Quick Facts Leptin, 有效结构 ...Leptin PDB解译基于1ax8. 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1AX8 标识代号 LEP; LEPD; OB; OBS扩展标识 遗传学:164160 鼠基因:104663 同源基因:193 GeneCards: LEP Gene 基因本体论描述 分子功能 · hormone activity · growth factor activity · peptide hormone receptor binding 细胞成分 · extracellular region · extracellular space 生物过程 · negative regulation of transcription from RNA polymerase II promoter · ovulation from ovarian follicle · response to hypoxia · positive regulation of cytokine production · placenta development · response to dietary excess · glucose metabolic process · regulation of gluconeogenesis · energy reserve metabolic process · glycerol biosynthetic process · tyrosine phosphorylation of STAT protein · female pregnancy · circadian rhythm · cholesterol metabolic process · bile acid metabolic process · regulation of blood pressure · positive regulation of cell proliferation · adult feeding behavior · fatty acid catabolic process · central nervous system neuron development · insulin secretion · regulation of intestinal cholesterol absorption · negative regulation of appetite · response to insulin stimulus · response to vitamin E · leptin-mediated signaling pathway · positive regulation of luteinizing hormone secretion · bone mineralization involved in bone maturation · hormone metabolic process · positive regulation of tyrosine phosphorylation of Stat3 protein · eating behavior · negative regulation of apoptotic process · positive regulation of ion transport · positive regulation of MAPK cascade · positive regulation of myeloid cell differentiation · negative regulation of vasoconstriction · positive regulation of insulin receptor signaling pathway · positive regulation of follicle-stimulating hormone secretion · positive regulation of developmental growth · regulation of insulin secretion · regulation of steroid biosynthetic process · leukocyte tethering or rolling · regulation of lipoprotein lipid oxidation · adipose tissue development · negative regulation of cartilage development · negative regulation of glucagon secretion · cellular response to L-ascorbic acid · cellular response to retinoic acid · positive regulation of STAT protein import into nucleus · negative regulation of glutamine transport · positive regulation of hepatic stellate cell activation Sources: Amigo / QuickGO RNA表达模式 更多表达数据直系同源体物种 人类 小鼠Entrez 3952 16846Ensembl ENSG00000174697 ENSMUSG00000059201UniProt P41159 P41160mRNA序列 NM_000230 NM_008493蛋白序列 NP_000221 NP_032519基因位置 Chr 7:127.88 – 127.9 Mb Chr 6:29.06 – 29.07 MbPubMed查询 [1] [2]查论编Close
Quick Facts Leptin, 有效结构 ...Leptin PDB解译基于1ax8. 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1AX8 标识代号 LEP; LEPD; OB; OBS扩展标识 遗传学:164160 鼠基因:104663 同源基因:193 GeneCards: LEP Gene 基因本体论描述 分子功能 · hormone activity · growth factor activity · peptide hormone receptor binding 细胞成分 · extracellular region · extracellular space 生物过程 · negative regulation of transcription from RNA polymerase II promoter · ovulation from ovarian follicle · response to hypoxia · positive regulation of cytokine production · placenta development · response to dietary excess · glucose metabolic process · regulation of gluconeogenesis · energy reserve metabolic process · glycerol biosynthetic process · tyrosine phosphorylation of STAT protein · female pregnancy · circadian rhythm · cholesterol metabolic process · bile acid metabolic process · regulation of blood pressure · positive regulation of cell proliferation · adult feeding behavior · fatty acid catabolic process · central nervous system neuron development · insulin secretion · regulation of intestinal cholesterol absorption · negative regulation of appetite · response to insulin stimulus · response to vitamin E · leptin-mediated signaling pathway · positive regulation of luteinizing hormone secretion · bone mineralization involved in bone maturation · hormone metabolic process · positive regulation of tyrosine phosphorylation of Stat3 protein · eating behavior · negative regulation of apoptotic process · positive regulation of ion transport · positive regulation of MAPK cascade · positive regulation of myeloid cell differentiation · negative regulation of vasoconstriction · positive regulation of insulin receptor signaling pathway · positive regulation of follicle-stimulating hormone secretion · positive regulation of developmental growth · regulation of insulin secretion · regulation of steroid biosynthetic process · leukocyte tethering or rolling · regulation of lipoprotein lipid oxidation · adipose tissue development · negative regulation of cartilage development · negative regulation of glucagon secretion · cellular response to L-ascorbic acid · cellular response to retinoic acid · positive regulation of STAT protein import into nucleus · negative regulation of glutamine transport · positive regulation of hepatic stellate cell activation Sources: Amigo / QuickGO RNA表达模式 更多表达数据直系同源体物种 人类 小鼠Entrez 3952 16846Ensembl ENSG00000174697 ENSMUSG00000059201UniProt P41159 P41160mRNA序列 NM_000230 NM_008493蛋白序列 NP_000221 NP_032519基因位置 Chr 7:127.88 – 127.9 Mb Chr 6:29.06 – 29.07 MbPubMed查询 [1] [2]查论编Close