模板:PBB/5728维基媒体模板 / 维基百科,自由的 encyclopedia Quick Facts 磷酸酯酶与张力蛋白同源物, 有效结构 ...磷酸酯酶与张力蛋白同源物 人PTEN的晶体结构图。N-端磷酸酯酶结构域以蓝色表示而C-端C2结构域以红色表示[1]。 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1D5R, 2KYL 标识代号 PTEN; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1扩展标识 遗传学:601728 鼠基因:109583 同源基因:265 GeneCards: PTEN GeneEC编号 3.1.3.16, 3.1.3.48, 3.1.3.67 基因本体论描述 分子功能 · magnesium ion binding · phosphatidylinositol-3-phosphatase activity · phosphoprotein phosphatase activity · protein serine/threonine phosphatase activity · protein tyrosine phosphatase activity · protein binding · protein tyrosine/serine/threonine phosphatase activity · lipid binding · anaphase-promoting complex binding · phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity · enzyme binding · protein kinase binding · PDZ domain binding · inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity · phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity 细胞成分 · nucleus · cytoplasm · cytosol · plasma membrane · internal side of plasma membrane · PML body · myelin sheath adaxonal region · cell projection · neuron projection · Schmidt-Lanterman incisure 生物过程 · regulation of cyclin-dependent protein serine/threonine kinase activity · angiogenesis · negative regulation of protein phosphorylation · regulation of B cell apoptotic process · protein dephosphorylation · phospholipid metabolic process · phosphatidylinositol biosynthetic process · apoptotic process · induction of apoptosis · activation of mitotic anaphase-promoting complex activity · epidermal growth factor receptor signaling pathway · neuron-neuron synaptic transmission · synapse assembly · central nervous system development · heart development · learning or memory · locomotory behavior · cell proliferation · positive regulation of cell proliferation · negative regulation of cell proliferation · fibroblast growth factor receptor signaling pathway · regulation of neuron projection development · negative regulation of phosphatidylinositol 3-kinase cascade · cell migration · dentate gyrus development · central nervous system neuron axonogenesis · negative regulation of cell migration · negative regulation of myelination · regulation of protein stability · negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S · central nervous system myelin maintenance · regulation of cellular component size · regulation of myeloid cell apoptotic process · multicellular organismal response to stress · social behavior · peptidyl-tyrosine dephosphorylation · maternal behavior · negative regulation of apoptotic process · protein kinase B signaling cascade · endothelial cell migration · inositol phosphate metabolic process · small molecule metabolic process · innate immune response · locomotor rhythm · negative regulation of cell size · negative regulation of organ growth · inositol phosphate dephosphorylation · phosphatidylinositol dephosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · cardiac muscle tissue development · forebrain morphogenesis · brain morphogenesis · negative regulation of epithelial cell proliferation · negative regulation of axonogenesis · protein stabilization · T cell receptor signaling pathway · positive regulation of sequence-specific DNA binding transcription factor activity · negative regulation of focal adhesion assembly · negative regulation of protein kinase B signaling cascade · rhythmic synaptic transmission · canonical Wnt receptor signaling pathway · synapse maturation · prepulse inhibition · male mating behavior · long-term synaptic potentiation · prostate gland growth · dendritic spine morphogenesis · negative regulation of dendritic spine morphogenesis · negative regulation of ribosome biogenesis · negative regulation of cell aging · negative regulation of excitatory postsynaptic membrane potential · presynaptic membrane assembly · postsynaptic density assembly · positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process · negative regulation of G1/S transition of mitotic cell cycle · positive regulation of excitatory postsynaptic membrane potential · negative regulation of synaptic vesicle clustering Sources: Amigo / QuickGO 直系同源体物种 人类 小鼠Entrez 5728 19211Ensembl ENSG00000171862 ENSMUSG00000013663UniProt P60484 O08586mRNA序列 NM_000314 NM_008960蛋白序列 NP_000305 NP_032986基因位置 Chr 10:89.62 – 89.73 Mb Chr 19:32.76 – 32.83 MbPubMed查询 [1] [2]查论编Close
Quick Facts 磷酸酯酶与张力蛋白同源物, 有效结构 ...磷酸酯酶与张力蛋白同源物 人PTEN的晶体结构图。N-端磷酸酯酶结构域以蓝色表示而C-端C2结构域以红色表示[1]。 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1D5R, 2KYL 标识代号 PTEN; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1扩展标识 遗传学:601728 鼠基因:109583 同源基因:265 GeneCards: PTEN GeneEC编号 3.1.3.16, 3.1.3.48, 3.1.3.67 基因本体论描述 分子功能 · magnesium ion binding · phosphatidylinositol-3-phosphatase activity · phosphoprotein phosphatase activity · protein serine/threonine phosphatase activity · protein tyrosine phosphatase activity · protein binding · protein tyrosine/serine/threonine phosphatase activity · lipid binding · anaphase-promoting complex binding · phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity · enzyme binding · protein kinase binding · PDZ domain binding · inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity · phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity 细胞成分 · nucleus · cytoplasm · cytosol · plasma membrane · internal side of plasma membrane · PML body · myelin sheath adaxonal region · cell projection · neuron projection · Schmidt-Lanterman incisure 生物过程 · regulation of cyclin-dependent protein serine/threonine kinase activity · angiogenesis · negative regulation of protein phosphorylation · regulation of B cell apoptotic process · protein dephosphorylation · phospholipid metabolic process · phosphatidylinositol biosynthetic process · apoptotic process · induction of apoptosis · activation of mitotic anaphase-promoting complex activity · epidermal growth factor receptor signaling pathway · neuron-neuron synaptic transmission · synapse assembly · central nervous system development · heart development · learning or memory · locomotory behavior · cell proliferation · positive regulation of cell proliferation · negative regulation of cell proliferation · fibroblast growth factor receptor signaling pathway · regulation of neuron projection development · negative regulation of phosphatidylinositol 3-kinase cascade · cell migration · dentate gyrus development · central nervous system neuron axonogenesis · negative regulation of cell migration · negative regulation of myelination · regulation of protein stability · negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S · central nervous system myelin maintenance · regulation of cellular component size · regulation of myeloid cell apoptotic process · multicellular organismal response to stress · social behavior · peptidyl-tyrosine dephosphorylation · maternal behavior · negative regulation of apoptotic process · protein kinase B signaling cascade · endothelial cell migration · inositol phosphate metabolic process · small molecule metabolic process · innate immune response · locomotor rhythm · negative regulation of cell size · negative regulation of organ growth · inositol phosphate dephosphorylation · phosphatidylinositol dephosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · cardiac muscle tissue development · forebrain morphogenesis · brain morphogenesis · negative regulation of epithelial cell proliferation · negative regulation of axonogenesis · protein stabilization · T cell receptor signaling pathway · positive regulation of sequence-specific DNA binding transcription factor activity · negative regulation of focal adhesion assembly · negative regulation of protein kinase B signaling cascade · rhythmic synaptic transmission · canonical Wnt receptor signaling pathway · synapse maturation · prepulse inhibition · male mating behavior · long-term synaptic potentiation · prostate gland growth · dendritic spine morphogenesis · negative regulation of dendritic spine morphogenesis · negative regulation of ribosome biogenesis · negative regulation of cell aging · negative regulation of excitatory postsynaptic membrane potential · presynaptic membrane assembly · postsynaptic density assembly · positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process · negative regulation of G1/S transition of mitotic cell cycle · positive regulation of excitatory postsynaptic membrane potential · negative regulation of synaptic vesicle clustering Sources: Amigo / QuickGO 直系同源体物种 人类 小鼠Entrez 5728 19211Ensembl ENSG00000171862 ENSMUSG00000013663UniProt P60484 O08586mRNA序列 NM_000314 NM_008960蛋白序列 NP_000305 NP_032986基因位置 Chr 10:89.62 – 89.73 Mb Chr 19:32.76 – 32.83 MbPubMed查询 [1] [2]查论编Close