模板:PBB/7124维基媒体模板 / 维基百科,自由的 encyclopedia Quick Facts 肿瘤坏死因子, 有效结构 ...肿瘤坏死因子 PDB rendering based on 1TNF. 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 4TSV, 5TSW 标识代号 TNF; DIF; TNF-alpha; TNFA; TNFSF2扩展标识 遗传学:191160 鼠基因:104798 同源基因:496 ChEMBL: 1825 GeneCards: TNF Gene 基因本体论描述 分子功能 · protease binding · cytokine activity · tumor necrosis factor receptor binding · protein binding · identical protein binding · transcription regulatory region DNA binding 细胞成分 · phagocytic cup · extracellular space · plasma membrane · integral to plasma membrane · external side of plasma membrane · cell surface · membrane raft · recycling endosome 生物过程 · protein import into nucleus, translocation · negative regulation of transcription from RNA polymerase II promoter · MAPK cascade · activation of MAPKKK activity · activation of MAPK activity · response to hypoxia · cell activation · positive regulation of cytokine production · positive regulation of protein phosphorylation · negative regulation of L-glutamate transport · chronic inflammatory response to antigenic stimulus · negative regulation of cytokine secretion involved in immune response · positive regulation of chronic inflammatory response to antigenic stimulus · positive regulation of humoral immune response mediated by circulating immunoglobulin · skeletal muscle contraction · glucose metabolic process · apoptotic process · anti-apoptosis · induction of apoptosis · activation of cysteine-type endopeptidase activity involved in apoptotic process · transformed cell apoptotic process · inflammatory response · humoral immune response · JNK cascade · negative regulation of cell proliferation · induction of apoptosis by extracellular signals · induction of apoptosis by extracellular signals · induction of apoptosis via death domain receptors · response to mechanical stimulus · response to virus · response to salt stress · organ morphogenesis · negative regulation of gene expression · negative regulation of alkaline phosphatase activity · negative regulation of lipid storage · positive regulation of necrotic cell death · response to activity · calcium-mediated signaling · extracellular matrix organization · sequestering of triglyceride · positive regulation of protein complex assembly · positive regulation of fever generation · lipopolysaccharide-mediated signaling pathway · negative regulation of interleukin-6 production · positive regulation of chemokine production · positive regulation of interferon-gamma production · positive regulation of interleukin-6 production · receptor biosynthetic process · positive regulation of peptidyl-serine phosphorylation · tumor necrosis factor-mediated signaling pathway · positive regulation of heterotypic cell-cell adhesion · positive regulation of NF-kappaB import into nucleus · response to drug · positive regulation of apoptotic process · positive regulation of apoptotic process · negative regulation of apoptotic process · positive regulation of programmed cell death · regulation of I-kappaB kinase/NF-kappaB cascade · positive regulation of I-kappaB kinase/NF-kappaB cascade · positive regulation of protein complex disassembly · positive regulation of MAP kinase activity · protein kinase B signaling cascade · positive regulation of neuron apoptotic process · negative regulation of growth of symbiont in host · negative regulation of viral genome replication · positive regulation of chemokine biosynthetic process · positive regulation of interleukin-8 biosynthetic process · positive regulation of nitric oxide biosynthetic process · negative regulation of fat cell differentiation · negative regulation of osteoblast differentiation · positive regulation of osteoclast differentiation · positive regulation of mitosis · negative regulation of transcription, DNA-dependent · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · positive regulation of transcription from RNA polymerase II promoter · positive regulation of translational initiation by iron · negative regulation of glucose import · positive regulation of JNK cascade · embryonic digestive tract development · positive regulation of smooth muscle cell proliferation · positive regulation of cytokine secretion · regulation of insulin secretion · positive regulation of synaptic transmission · defense response to Gram-positive bacterium · leukocyte tethering or rolling · negative regulation of lipid catabolic process · regulation of immunoglobulin secretion · positive regulation of membrane protein ectodomain proteolysis · positive regulation of sequence-specific DNA binding transcription factor activity · positive regulation of NF-kappaB transcription factor activity · positive regulation of protein transport · response to glucocorticoid stimulus · positive regulation of NFAT protein import into nucleus · positive regulation of hair follicle development · positive regulation of protein kinase B signaling cascade · induction of necroptosis by extracellular signals · positive regulation of vitamin D biosynthetic process · positive regulation of calcidiol 1-monooxygenase activity · epithelial cell proliferation involved in salivary gland morphogenesis · regulation of branching involved in salivary gland morphogenesis · negative regulation of branching involved in lung morphogenesis · necrotic cell death · positive regulation of ERK1 and ERK2 cascade · cellular response to amino acid stimulus · cellular response to nicotine · cellular response to organic cyclic compound · positive regulation of mononuclear cell migration · positive regulation of podosome assembly · extrinsic apoptotic signaling pathway · positive regulation of protein localization at cell surface · positive regulation of chemokine (C-X-C motif) ligand 2 production Sources: Amigo / QuickGO RNA表达模式 更多表达数据直系同源体物种 人类 小鼠Entrez 7124 21926Ensembl ENSG00000204490 ENSMUSG00000024401UniProt P01375 P06804mRNA序列 NM_000594.3 NM_013693.2蛋白序列 NP_000585.2 NP_038721.1基因位置 Chr 6:31.54 – 31.55 Mb Chr 17:35.2 – 35.2 MbPubMed查询 [1] [2]查论编Close
Quick Facts 肿瘤坏死因子, 有效结构 ...肿瘤坏死因子 PDB rendering based on 1TNF. 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 4TSV, 5TSW 标识代号 TNF; DIF; TNF-alpha; TNFA; TNFSF2扩展标识 遗传学:191160 鼠基因:104798 同源基因:496 ChEMBL: 1825 GeneCards: TNF Gene 基因本体论描述 分子功能 · protease binding · cytokine activity · tumor necrosis factor receptor binding · protein binding · identical protein binding · transcription regulatory region DNA binding 细胞成分 · phagocytic cup · extracellular space · plasma membrane · integral to plasma membrane · external side of plasma membrane · cell surface · membrane raft · recycling endosome 生物过程 · protein import into nucleus, translocation · negative regulation of transcription from RNA polymerase II promoter · MAPK cascade · activation of MAPKKK activity · activation of MAPK activity · response to hypoxia · cell activation · positive regulation of cytokine production · positive regulation of protein phosphorylation · negative regulation of L-glutamate transport · chronic inflammatory response to antigenic stimulus · negative regulation of cytokine secretion involved in immune response · positive regulation of chronic inflammatory response to antigenic stimulus · positive regulation of humoral immune response mediated by circulating immunoglobulin · skeletal muscle contraction · glucose metabolic process · apoptotic process · anti-apoptosis · induction of apoptosis · activation of cysteine-type endopeptidase activity involved in apoptotic process · transformed cell apoptotic process · inflammatory response · humoral immune response · JNK cascade · negative regulation of cell proliferation · induction of apoptosis by extracellular signals · induction of apoptosis by extracellular signals · induction of apoptosis via death domain receptors · response to mechanical stimulus · response to virus · response to salt stress · organ morphogenesis · negative regulation of gene expression · negative regulation of alkaline phosphatase activity · negative regulation of lipid storage · positive regulation of necrotic cell death · response to activity · calcium-mediated signaling · extracellular matrix organization · sequestering of triglyceride · positive regulation of protein complex assembly · positive regulation of fever generation · lipopolysaccharide-mediated signaling pathway · negative regulation of interleukin-6 production · positive regulation of chemokine production · positive regulation of interferon-gamma production · positive regulation of interleukin-6 production · receptor biosynthetic process · positive regulation of peptidyl-serine phosphorylation · tumor necrosis factor-mediated signaling pathway · positive regulation of heterotypic cell-cell adhesion · positive regulation of NF-kappaB import into nucleus · response to drug · positive regulation of apoptotic process · positive regulation of apoptotic process · negative regulation of apoptotic process · positive regulation of programmed cell death · regulation of I-kappaB kinase/NF-kappaB cascade · positive regulation of I-kappaB kinase/NF-kappaB cascade · positive regulation of protein complex disassembly · positive regulation of MAP kinase activity · protein kinase B signaling cascade · positive regulation of neuron apoptotic process · negative regulation of growth of symbiont in host · negative regulation of viral genome replication · positive regulation of chemokine biosynthetic process · positive regulation of interleukin-8 biosynthetic process · positive regulation of nitric oxide biosynthetic process · negative regulation of fat cell differentiation · negative regulation of osteoblast differentiation · positive regulation of osteoclast differentiation · positive regulation of mitosis · negative regulation of transcription, DNA-dependent · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · positive regulation of transcription from RNA polymerase II promoter · positive regulation of translational initiation by iron · negative regulation of glucose import · positive regulation of JNK cascade · embryonic digestive tract development · positive regulation of smooth muscle cell proliferation · positive regulation of cytokine secretion · regulation of insulin secretion · positive regulation of synaptic transmission · defense response to Gram-positive bacterium · leukocyte tethering or rolling · negative regulation of lipid catabolic process · regulation of immunoglobulin secretion · positive regulation of membrane protein ectodomain proteolysis · positive regulation of sequence-specific DNA binding transcription factor activity · positive regulation of NF-kappaB transcription factor activity · positive regulation of protein transport · response to glucocorticoid stimulus · positive regulation of NFAT protein import into nucleus · positive regulation of hair follicle development · positive regulation of protein kinase B signaling cascade · induction of necroptosis by extracellular signals · positive regulation of vitamin D biosynthetic process · positive regulation of calcidiol 1-monooxygenase activity · epithelial cell proliferation involved in salivary gland morphogenesis · regulation of branching involved in salivary gland morphogenesis · negative regulation of branching involved in lung morphogenesis · necrotic cell death · positive regulation of ERK1 and ERK2 cascade · cellular response to amino acid stimulus · cellular response to nicotine · cellular response to organic cyclic compound · positive regulation of mononuclear cell migration · positive regulation of podosome assembly · extrinsic apoptotic signaling pathway · positive regulation of protein localization at cell surface · positive regulation of chemokine (C-X-C motif) ligand 2 production Sources: Amigo / QuickGO RNA表达模式 更多表达数据直系同源体物种 人类 小鼠Entrez 7124 21926Ensembl ENSG00000204490 ENSMUSG00000024401UniProt P01375 P06804mRNA序列 NM_000594.3 NM_013693.2蛋白序列 NP_000585.2 NP_038721.1基因位置 Chr 6:31.54 – 31.55 Mb Chr 17:35.2 – 35.2 MbPubMed查询 [1] [2]查论编Close