糖蛋白激素α亚基

糖蛋白激素α亚基（英语：Alpha subunit of glycoprotein hormones，或称为绒毛膜促性腺激素α亚基，Glycoprotein hormones alpha chain）是一个由人类基因CGA 编码的蛋白质^[1]。

Glycoprotein hormones, alpha polypeptide 绒毛膜促性腺激素，α多肽
PDB rendering based on 1dz7.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1DZ7​, 1E9J​, 1FL7​, 1HCN​, 1HD4​, 1HRP​, 1QFW​, 1XWD​, 4AY9​
标识
代号	CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
扩展标识	遗传学：118850 鼠基因：88390 同源基因：587 GeneCards: CGA Gene
基因本体论描述 分子功能 · hormone activity · protein binding 细胞成分 · extracellular region 生物过程 · thyroid hormone generation · signal transduction · cell-cell signaling · positive regulation of cell proliferation · gonad development · peptide hormone processing · positive regulation of cell migration · thyroid gland development · luteinizing hormone secretion · cellular response to hormone stimulus · cellular protein metabolic process · positive regulation of transcription from RNA polymerase II promoter · negative regulation of organ growth · follicle-stimulating hormone secretion · developmental growth Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	1081	12640
Ensembl	ENSG00000135346	ENSMUSG00000028298
UniProt	P01215	P01216
mRNA序列	NM_000735	NM_009889
蛋白序列	NP_000726	NP_034019
基因位置	Chr 6: 87.8 – 87.8 Mb	Chr 4: 34.89 – 34.91 Mb
PubMed查询	[1]	[2]
查 论 编

人体的四种糖蛋白激素（英语：glycoprotein hormones）--人绒毛膜促性腺激素（hCG）、黄体生成素（LH）、促卵泡激素（FSH）和促甲状腺激素（TSH）都是以同样的该α亚基和各自不同的β亚基组成的二聚体。^[2]化学式为^[3]：C₅₆₁H₈₇₆O₂₂₄N₁₃₀S₁₃^[4]

此α链的92个氨基酸残基的序列为：

NH₂ - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH