STAT1

STAT1是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。

STAT1
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 3WWT、​1BF5、​1YVL、​2KA6
识别号
别名	STAT1；, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部ID	OMIM：600555 MGI：103063 HomoloGene：21428 GeneCards：STAT1
相关疾病
慢性黏膜皮肤念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置（人类） 染色体 2号染色体[2] 基因座 2q32.2 起始 190,908,460 bp[2] 终止 191,020,960 bp[2]
基因位置（小鼠） 染色体 小鼠1号染色体[3] 基因座 1 C1.1|1 26.81 cM 起始 52,158,599 bp[3] 终止 52,201,024 bp[3]
RNA表达模式
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基因本体 分子功能 • DNA结合 • protein homodimerization activity • DNA结合转录因子活性 • RNA polymerase II general transcription initiation factor activity • signal transducer activity • RNA polymerase II cis-regulatory region sequence-specific DNA binding • 血浆蛋白结合 • 相同蛋白质结合 • 酶结合 • tumor necrosis factor receptor binding • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • cadherin binding • histone acetyltransferase binding • histone binding • ubiquitin-like protein ligase binding • promoter-specific chromatin binding • sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • CCR5 chemokine receptor binding • protein phosphatase 2A binding • DNA-binding transcription activator activity, RNA polymerase II-specific 细胞组分 • 细胞质 • 核质 • 核仁 • 细胞质的核周区域 • 细胞核 • 细胞质基质 • 轴突 • 树突 • 大分子复合体 生物学过程 • regulation of apoptotic process • metanephric mesenchymal cell proliferation involved in metanephros development • regulation of transcription, DNA-templated • cellular response to interferon-beta • regulation of transcription by RNA polymerase II • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • tumor necrosis factor-mediated signaling pathway • negative regulation of transcription by RNA polymerase II • renal tubule development • response to interferon-beta • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of endothelial cell proliferation • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • positive regulation of mesenchymal cell proliferation • negative regulation of metanephric nephron tubule epithelial cell differentiation • negative regulation of angiogenesis • negative regulation by virus of viral protein levels in host cell • viral process • endothelial cell migration • positive regulation of transcription by RNA polymerase II • 信号转导 • macrophage derived foam cell differentiation • positive regulation of erythrocyte differentiation • type I interferon signaling pathway • cellular response to interferon-gamma • positive regulation of defense response to virus by host • positive regulation of interferon-alpha production • positive regulation of transcription, DNA-templated • defense response to virus • interferon-gamma-mediated signaling pathway • receptor signaling pathway via JAK-STAT • response to nutrient • blood circulation • positive regulation of cell population proliferation • response to mechanical stimulus • response to organic cyclic compound • cellular response to insulin stimulus • response to cytokine • response to hydrogen peroxide • response to peptide hormone • positive regulation of smooth muscle cell proliferation • response to cAMP • positive regulation of nitric-oxide synthase biosynthetic process • cellular response to cytokine stimulus • cellular response to organic cyclic compound • positive regulation of transcription of Notch receptor target • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • interleukin-6-mediated signaling pathway • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway • interleukin-9-mediated signaling pathway • defense response • regulation of cell population proliferation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	6772	20846
Ensembl	ENSG00000115415	ENSMUSG00000026104
UniProt	P42224	P42225
mRNA​序列	​NM_007315 ​NM_139266	NM_001205313 ​NM_001205314 ​NM_009283 ​NM_001357627
蛋白序列	NP_009330 ​NP_644671	无数据
基因位置​（UCSC）	Chr 2: 190.91 – 191.02 Mb	Chr 1: 52.16 – 52.2 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

STAT1涉及I型、II型或III型干扰素激活基因的正调控。在干扰素-γ刺激下，STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS（Interferon-Gamma-Activated Sequence，干扰素γ激活序列）启动子上；而在干扰素-α或干扰素-β刺激下，STAT1会与STAT2组成异二聚体结合到ISRE（Interferon-Stimulated Response Element，干扰素激活反应元件）启动子上^[6]。在这两种情况下，STAT二聚体与启动子的结合都会导致ISG（Interferon-Stimulated Genes，干扰素激活基因）的表达。

STAT1可由二烯丙基二硫诱导表达^[7]

相互作用

STAT1能与下列蛋白质发生相互作用：

• 蛋白激酶R（英语：Protein kinase R）^[8][9]
• Src^[10][11]
• IRF1^[12]
• STAT3^[13][14][15]
• MCM5^[16][17]
• STAT2^[18][19][20]
• CD117^[21]
• Fanconi anemia, complementation group C^[22][23][24]
• CREB结合蛋白（英语：CREB-binding protein）^[25]
• 白介素27受体α亚基（英语：Interleukin 27 receptor, alpha subunit）^[26]
• PIAS1^[27]
• BRCA1^[28]
• 表皮生长因子受体^[10][15]
• PTK2^[29]
• Mammalian target of rapamycin^[30]
• IFNAR2^[31][32]
• PRKCD^[30]
• TRADD^[33]
• C-jun^[34]
• Calcitriol receptor^[35]
• ISGF3G^[36]
• GNB2L1^[32][37]