4-羥基雌二醇

4-羥基雌二醇
	IUPAC名; (8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol
別名	4-OHE2; Estra-1,3,5(10)-triene-3,4,17β-triol; 3,4,17β-Trihydroxyestra-1,3,5(10)-triene
識別
CAS號	5976-61-4
PubChem	5282360
ChemSpider	4445523
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4O)O;
ChEBI	62845
KEGG	C14209
性質
化學式	C18H24O3
摩爾質量	288.38 g·mol−1
熔點	252—253 °C（525—526 K）
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

4-羥基雌二醇（英語：4-Hydroxyestradiol，縮寫4-OHE2，或稱為雌甾-1,3,5(10)-三烯-3,4,17β-三醇，estra-1,3,5(10)-triene-3,4,17β-triol）是一種內源性的天然兒茶酚雌激素和雌酮與雌二醇的次要代謝產物^[2]，帶有一定的雌激素活性^[2]^[3]。

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參考資料

[1]
Hecker, Erich; Walk, Elisabeth. The chemistry of the p-quinols. III. o-Quinone diacetates and amino analogs of natural estrogens. Chemische Berichte, 1960. 93: 2928-2937. ISSN: 0009-2940.
[2]
Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.
[3]
Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.

外部連結

Metabocard for 4-Hydroxyestradiol - Human Metabolome Database （頁面存檔備份，存於網際網路檔案館）

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[1] [1]
Hecker, Erich; Walk, Elisabeth. The chemistry of the p-quinols. III. o-Quinone diacetates and amino analogs of natural estrogens. Chemische Berichte, 1960. 93: 2928-2937. ISSN: 0009-2940.

[OettelSchillinger2012-2] [2]
Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.

[pmid10865186-3] [3]
Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.

[2]

[3]

[1]