甲狀腺激素α受體

甲狀腺激素α受體
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	1NAV、2H77、2H79、3HZF、3ILZ、3JZB、4LNW、4LNX
識別號
別名	THRA；, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha
外部ID	OMIM：190120 MGI：98742 HomoloGene：37747 GeneCards：THRA
相關疾病
	congenital nongoitrous hypothryoidism 6
為以下藥物的標靶
	反三碘甲狀腺原胺酸、替拉曲可、三碘甲腺原胺酸、左旋甲狀腺素鈉
基因位置（人類）
染色體	17號染色體
終止	40,093,867 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	98,659,832 bp
RNA表現模式
	; ;
	查閱更多表現資料
基因本體
分子功能	• transcription cis-regulatory region binding; • 血漿蛋白結合; • single-stranded RNA binding; • 鋅離子結合; • chromatin DNA binding; • nuclear receptor activity; • steroid receptor RNA activator RNA binding; • 轉錄因子結合; • TBP-class protein binding; • steroid hormone receptor activity; • DNA結合; • protein domain specific binding; • sequence-specific DNA binding; • 金屬離子結合; • DNA結合轉錄因子活性; • thyroid hormone binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • 大分子複合物結合; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • nuclear receptor coactivator activity; • signaling receptor activity;
細胞組分	• 細胞質; • 核質; • 細胞核; • 細胞質基質; • RNA polymerase II transcription regulator complex;
生物學過程	• regulation of transcription by RNA polymerase II; • response to cold; • cytoplasmic sequestering of transcription factor; • hormone-mediated signaling pathway; • regulation of thyroid hormone mediated signaling pathway; • 副甲狀腺的發生; • regulation of transcription, DNA-templated; • 成骨作用; • female courtship behavior; • cartilage condensation; • negative regulation of RNA polymerase II transcription preinitiation complex assembly; • type I pneumocyte differentiation; • transcription, DNA-templated; • steroid hormone mediated signaling pathway; • transcription by RNA polymerase II; • regulation of lipid catabolic process; • regulation of heart contraction; • animal organ morphogenesis; • positive regulation of female receptivity; • 學習和記憶; • regulation of myeloid cell apoptotic process; • positive regulation of transcription by RNA polymerase II; • transcription initiation from RNA polymerase II promoter; • erythrocyte differentiation; • negative regulation of DNA-templated transcription, initiation; • positive regulation of myotube differentiation; • negative regulation of transcription, DNA-templated; • intracellular receptor signaling pathway; • negative regulation of transcription by RNA polymerase II; • thyroid hormone mediated signaling pathway; • multicellular organism development; • brain development; • 細胞分化; • response to lipid; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	7067
	21833
	ENSG00000126351
	ENSMUSG00000058756
	P10827
	P63058
	NM_199334; NM_001190918; NM_001190919; NM_003250
	NM_178060; NM_001313983
	NP_001177847; NP_001177848; NP_003241; NP_955366
	NP_001300912; NP_835161
	維基資料
檢視/編輯人類	檢視/編輯小鼠