白血球介素-6

白血球介素-6（Interleukin 6），簡稱白介素-6（IL-6，在人體內由IL6基因編碼^[5]），最初由日本免疫學家岸本忠三團隊發現^[6]，是一種介導發炎的白血球介素（但在某些情況下也具有抗發炎症作用）^[7][5]。白血球介素-6可由T細胞、B細胞、單核球、纖維母細胞、角質形成細胞、內皮細胞、繫膜細胞（英語：mesangial cell），以及一部分腫瘤細胞分泌^[8]。

白細胞介素6
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 4O9H、​1ALU、​1IL6、​1P9M、​2IL6、​4CNI、​4J4L、​4NI7、​4NI9、​4ZS7
識別號
別名	IL6；, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
外部ID	OMIM：147620 MGI：96559 HomoloGene：502 GeneCards：IL6
基因位置（人類） 染色體 7號染色體[1] 基因座 7p15.3 起始 22,725,884 bp[1] 終止 22,732,002 bp[1]
基因位置（小鼠） 染色體 小鼠5號染色體[2] 基因座 5 B1|5 15.7 cM 起始 30,218,112 bp[2] 終止 30,224,979 bp[2]
RNA表現模式
查閱更多表現資料
基因本體 分子功能 • 細胞因子活性 • 生長因子活性 • interleukin-6 receptor binding • 血漿蛋白結合 細胞組分 • 細胞外區域 • interleukin-6 receptor complex • 細胞外空間 • endoplasmic reticulum lumen 生物學過程 • regulation of angiogenesis • positive regulation of translation • platelet activation • humoral immune response • defense response to virus • response to peptidoglycan • neuron projection development • defense response to Gram-positive bacterium • negative regulation of fat cell differentiation • positive regulation of peptidyl-serine phosphorylation • positive regulation of leukocyte chemotaxis • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of acute inflammatory response • inflammatory response • negative regulation of collagen biosynthetic process • positive regulation of MAPK cascade • hepatic immune response • monocyte chemotaxis • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • positive regulation of osteoblast differentiation • positive regulation of NF-kappaB transcription factor activity • 急性期反應 • 免疫反應 • regulation of vascular endothelial growth factor production • positive regulation of chemokine production • negative regulation of lipid storage • neutrophil mediated immunity • positive regulation of smooth muscle cell proliferation • positive regulation of type B pancreatic cell apoptotic process • response to glucocorticoid • defense response to Gram-negative bacterium • positive regulation of cell population proliferation • positive regulation of apoptotic process • positive regulation of B cell activation • 轉譯後修飾 • regulation of signaling receptor activity • positive regulation of tyrosine phosphorylation of STAT protein • neutrophil apoptotic process • negative regulation of cell population proliferation • positive regulation of gene expression • endocrine pancreas development • negative regulation of bone resorption • positive regulation of transcription, DNA-templated • positive regulation of transcription by RNA polymerase II • glucagon secretion • cellular response to hydrogen peroxide • cellular response to lipopolysaccharide • T-helper 17 cell lineage commitment • positive regulation of T-helper 2 cell cytokine production • negative regulation of interleukin-1-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • 訊息傳遞 Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3569	16193
Ensembl	ENSG00000136244	ENSMUSG00000025746
UniProt	P05231	P08505
mRNA​序列	NM_000600 ​NM_001318095 ​NM_001371096	NM_031168 ​NM_001314054
蛋白序列	NP_000591 ​NP_001305024 ​NP_001358025	NP_001300983 ​NP_112445
基因位置​（UCSC）	Chr 7: 22.73 – 22.73 Mb	Chr 5: 30.22 – 30.22 Mb
PubMed​查找	[3]	[4]
維基資料
檢視/編輯人類 檢視/編輯小鼠

白血球介素-6最初被認為是一種能促進B細胞分化為漿細胞的因子，後來陸續發現有其他功能^[9]。 例如，白血球介素-6能夠穿過血腦屏障^[10]，與中樞神經系統的正常生理過程與損傷修復過程都有關聯^[9]。