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芬太尼類物質
維基媒體列表條目 来自维基百科，自由的百科全书
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芬太尼類物質（fentanyl analogs，fentalogs[1][2]）是指芬太尼的類似物，滿足以下條件之一：
（1）丙醯基（用紅色標註）被其他醯基替代；
（2）與氮原子直接相連的苯基（用藍色標註）被任何取代或未取代的單環芳香基團替代；
（3）哌啶環（用橙色標註）上存在烷基、烯基、烷氧基、酯基、醚基、羥基、鹵素、鹵代烷基、氨基及硝基等取代基；
（4）苯乙基（用綠色標註）被使用除氫原子外的任意基團替代[3]。
列表
更多資訊 化學結構, 常用名 ...
| 化學結構 | 常用名 | 化學名 | CAS號 | 滿足條件 |
|---|---|---|---|---|
|
Thiophenylfentanyl (Thiofuranylfentanyl)[4] |
N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]thiophene-2-carboxamide | 2306823-38-9 | （1） |
|
3-呋喃基芬太尼 (3FUF) |
N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-3-carboxamide | 101343-82-2 | （1） |
|
2-呋喃基芬太尼 (Fu-F, FUF) |
N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide | 101345-66-8 | （1） |
|
四氫呋喃芬太尼 | N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]oxolane-2-carboxamide | 2142571-01-3 | （1） |
|
環戊基芬太尼 | N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]cyclopentanecarboxamide | 2088918-01-6 | （1） |
|
環丁基芬太尼[5] | N-[1-(2-Phenylethyl)piperidin-4-yl]-N-phenylcyclobutanecarboxamide | 2306827-55-2 | （1） |
|
環丙基芬太尼 | N-[1-(2-Phenylethyl)piperidin-4-yl]-N-phenylcyclopropanecarboxamide | 1169-68-2 | （1） |
|
四甲基環丙基芬太尼[6] | 2,2,3,3-Tetramethyl-N-(1-phenethylpiperidin-4-yl)-N-phenylcyclopropane-1-carboxamide | 2309383-11-5 | （1） |
|
巴豆醯芬太尼 | N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-2-butenamide | 760930-59-4 | （1） |
|
二甲烯丙醯芬太尼[7] | N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-3-methylbut-2-enamide | 2630378-28-6 | （1） |
|
丙烯醯芬太尼 | N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide | 82003-75-6 | （1） |
|
甲氧乙醯基芬太尼 (MAF) |
2-Methoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide | 101345-67-9 | （1） |
|
乙氧乙醯基芬太尼 | 2-ethoxy-N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide | （1） | |
|
乙醯芬太尼 | N-(1-Phenethylpiperidin-4-yl)-N-phenylacetamide | 3258-84-2 | （1） |
|
異丁醯芬太尼 | 2-methyl-N-phenyl-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]propanamide | 119618-70-1 | （1） |
|
丁醯芬太尼 (Bu-F, BUF) |
N-(1-(2-Phenylethyl)-4-piperidinyl)-N-phenylbutyramide | 1169-70-6 | （1） |
|
戊醯芬太尼 (VF) |
N-(1-(2-Phenylethyl)-4-piperidinyl)-N-phenylpentylamide | 122882-90-0 | （1） |
|
Fentanyl carbamate | ethyl N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]carbamate | 1465-20-9 | （1） |
|
脲芬太尼 Ureafentanyl |
N,N-dimethyl-N'-phenyl-N'-[1-(2-phenylethyl)-4-piperidinyl]-urea | 1443-50-1 | （1） |
|
Benzoylfentanyl | N-(1-Phenethylpiperidin-4-yl)-N-phenylbenzamide | 2309383-15-9 | （1） |
|
3-Phenylpropanoylfentanyl[8] | N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]-3-phenylpropanamide | 79279-02-0 | （1） |
|
Benzodioxolefentanyl[9] | N-Phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]-2H-1,3-benzodioxole-5-carboxamide | 2306823-01-6 | （1） |
|
Paramethylfentanyl (p-MF) | N-(4-methylphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide | 1838-67-1 | （2） |
|
4-Fluorofentanyl | N-(4-fluorophenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide | 90736-23-5 | （2） |
|
meta-fluorofentanyl | N-(3-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide | 90736-22-4 | （2） |
|
3-Methylfentanyl (3-MF) | N-(3-methyl-1-phenethyl-4-piperidyl)-N-phenyl-propanamide | 42045-86-3 | （3） |
|
2,5-Dimethylfentanyl | N-[2,5-Dimethyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide | 42045-97-6 | （3） |
|
3-Allylfentanyl | N-[(3S,4R)-1-Phenethyl-3-prop-2-enylpiperidin-4-yl]-N-phenylpropanamide | 82208-84-2 | （3） |
|
3-Fluorofentanyl (NFEPP) |
N-(3-Fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide | 1422952-84-8 | （3） |
|
Tetramethylfentanyl | N-(2,2,6,6-tetramethyl-1-phenethyl-4-piperidyl)-N-phenyl-propanamide | （3） | |
|
4-Phenylfentanyl | N-Phenyl-N-[4-phenyl-1-(2-phenylethyl)piperidin-4-yl]propanamide | 120448-97-7 | （3） |
|
卡芬太尼（英語：carfentanil） | Methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate | 59708-52-0 | （3） |
|
乙基卡芬太尼 | Ethyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate | （3） | |
|
MP102 | N-cycloheptyl-1-(2-phenylethyl)-4-(N-propanoylanilino)piperidine-4-carboxamide | （3） | |
|
MP135[10] | N-[4[2-(3-fluorophenyl)ethyl]carboxamido1-(2-phenylethyl)piperidin-4-yl]-N-benzylpropanamide | 2677687-49-7 | （3） |
|
Thenylfentanyl | N-phenyl-N-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]methyl}propanamide | 117332-93-1 | （4） |
|
苄基芬太尼 | N-(1-Benzylpiperidin-4-yl)-N-phenylpropanamide | 1474-02-8 | （4） |
|
高芬太尼 (N-phenylpropylnorfentanyl) [11] |
N-phenyl-N-[1-(3-phenylpropyl)piperidin-4-yl]propanamide | 59708-54-2 | （4） |
|
R-4173[12] | N-phenyl-N-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}propanamide | 2413-90-3 | （4） |
|
4"-Fluorofentanyl | N-[1-[2-(4-Fluorophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide | 2748343-99-7 | （4） |
|
阿法甲基芬太尼 (AMF) | N-phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]propanamide | 79704-88-4 | （4） |
|
阿法甲基硫代芬太尼 | N-Phenyl-N-[1-(1-thiophen-2-ylpropan-2-yl)-4-piperidyl]propanamide | 103963-66-2 | （4） |
|
α-Methyl-β-hydroxyfentanyl[13] | N-[1-(1-hydroxy-1-phenylpropan-2-yl)piperidin-4-yl]-N-phenylpropanamide | （4） | |
|
β-Methylfentanyl | N-Phenyl-N-[1-(2-phenylpropyl)piperidin-4-yl]propanamide | 79146-56-8 | （4） |
|
β-Hydroxyfentanyl | N-[1-(2-Hydroxy-2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide | 78995-10-5 | （4） |
|
β-Hydroxythiofentanyl | N1-[2-Hydroxy-2-(thiophen-2-yl)ethyl]piperidin-4-ylN-phenylpropanamide | 1474-34-6 | （4） |
|
2-Benzofuranylethyl-alpha-methylfentanyl | N-(1-[1-(1-Benzofuran-2-yl)-2-propanyl]-4-piperidinyl)-N-phenylpropanamide | （4） | |
|
trans-phenylcyclopropyl-norfentanyl | 1-(trans-2-Phenylcyclopropyl)-4-(N-propionylanilino)piperidine. | 102504-49-4 | （4） |
|
Furanylethylfentanyl (FUEF) | N-[1-[2-(2-furanyl)ethyl]-4-piperidinyl]-N-phenyl-propanamide | 802544-02-1 | （4） |
|
Pyridylfentany[14] | N-phenyl-N-[1-(2-pyridin-4-ylethyl)piperidin-4-yl]propanamide | 1443-41-0 | （4） |
|
N-(MDA)-fentanyl[15] | N-(1-(1-(benzo[d][1,3]dioxol-5-yl)propan-2-yl)piperidin-4-yl)-N-phenylpropionamide | （4） | |
-fentanyl_structure.png)
|
N-(2C-B)-fentanyl | N-(1-(2-(2,5-dimethoxy-4-bromophenyl)ethyl)piperidin-4-yl)-N-phenylpropionamide | （4） |
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更多資訊 化學結構, 常用名 ...
| 化學結構 | 常用名 | 化學名 | CAS號 | 滿足條件 |
|---|---|---|---|---|
|
2-Methylmethoxyacetylfentanyl | N-(2-Methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2-methoxyacetamide | 2748485-22-3 | （1）（2） |
|
2-Fluoroacrylfentanyl | N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propen-2-amide | 2309383-09-1 | （1）（2） |
|
2-Fluorobutyrfentanyl (o-FBF) | N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide | 2163847-76-3 | （1）（2） |
|
2-Fluoroisobutyrfentanyl (o-FIBF) | N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2-methylpropanamide | 2351142-33-9 | （1）（2） |
|
2-Methylacetylfentanyl (o-MAF) | N-(2-Methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-acetamide | 90736-11-1 | （1）（2） |
|
2,2'-Difluorofentanyl | N-(2-Fluorophenyl)-N-[1-(2-[2-fluorophenyl]ethyl)-4-piperidinyl]-propanamide | 2748343-87-3 | （2）（4） |
|
3-Methylbutyrfentanyl | N-[3-Methyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylbutanamide | 97605-09-9 | （1）（3） |
|
3-Methylcrotonylfentanyl | N-Phenyl-N-[1-(2-phenylethyl)-4-(3-methylpiperidin-1-yl)]-2-butenamide | 144480-29-5 | （1）（3） |
|
p-Methylcrotonylfentanyl | N-(4-methylphenyl)-N-[1-(2-phenylethyl)-4-(piperidin-1-yl)]-2-butenamide | 2734344-10-4 | （1）（2） |
|
3-Methylfuranylfentanyl[16] (3MFUF, TMFUF) | N-Phenyl-N-[3-methyl-1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide | （1）（3） | |
|
3-甲基硫代芬太尼 | N3-Methyl-1-[2-(2-thienyl)ethyl]piperidin-4-ylN-phenylpropanamide | 86052-04-2 | （3）（4） |
|
4-Fluorobutyrfentanyl (4-FBF) | N-(4-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide | 244195-31-1 | |
|
4-Chloroisobutyrylfentanyl (4-CIBF) [17] | 2-Methyl-N-(4-chlorophenyl)-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]propanamide | 244195-34-4 | |
|
4-Fluoroisobutyrfentanyl (4-FIBF) | N-(4-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-isobutanamide | 244195-32-2 | |
|
para-fluorofuranylfentanyl[18] (p-F-Fu-F) | N-(1-phenethylpiperidin-4-yl)-N-(4-fluorophenyl)furan-2-carboxamide | 1802489-71-9 | |
|
para-chlorofuranylfentanyl (p-Cl-Fu-F) | N-(1-phenethylpiperidin-4-yl)-N-(4-chlorophenyl)furan-2-carboxamide | ||
|
ortho-methylfuranylfentanyl (o-Me-Fu-F) | N-(1-phenethylpiperidin-4-yl)-N-(o-tolyl)furan-2-carboxamide | 2309383-07-9 | |
|
ortho-methoxyfuranylfentanyl (o-MeO-Fu-F) | N-(1-phenethylpiperidin-4-yl)-N-(2-methoxyphenyl)furan-2-carboxamide | 101343-50-4 | |
|
ortho-isopropylfuranylfentanyl (o-iPr-Fu-F) | N-(1-phenethylpiperidin-4-yl)-N-(2-isopropylphenyl)furan-2-carboxamide | ||
|
4-Methoxybutyrfentanyl | N-(4-Methoxyphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide | 2088842-68-4 | |
|
para-Hydroxy‐butyrylfentanyl [19] | N-(4-hydroxyphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-butanamide | ||
|
4"-Fluoro-o-fluoro-3-methylfentanyl | N-(2-fluorophenyl)-N-[1-[2-(4-fluorophenyl)ethyl]-3-methylpiperidin-4-yl]propanamide | ||
|
4-Methyl-methoxyacetylfentanyl (4-Me-MAF) | N-(4-Methylphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2-methoxyacetamide | ||
|
4-Methylphenethylacetylfentanyl[20] | N-[1-[2-(4-Methylphenyl)ethyl]-4-piperidinyl]-N-phenylacetamide | 1071703-95-1 | |
|
α-Methylacetylfentanyl | N-Phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]acetamide | 101860-00-8 | |
|
α-Methylbutyrfentanyl | N-phenyl-N-[1-(1-phenylpropan-2-yl)-4-piperidyl]butanamide | 244195-36-6 | |
|
阿芬太尼（英語：alfentanil） | N1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-ylN-phenylpropanamide | 71195-58-9 | |
|
BDBM50223545 (Berger Fentanyl) | 1-[2-(2-phenylethyl)-3,4,4a,9b-tetrahydro-1H-pyrido[4,3-b]indol-5-yl]propan-1-one | ||
|
β-Hydroxy-4-methylfentanyl | N-[1-(2-hydroxy-2-phenylethyl)-4-methylpiperidin-4-yl]-N-phenylpropanamide | ||
|
Brorphine[23] | 11-[1-(4-bromophenyl)ethyl]piperidin-4-yl1,3-dihydro-2H-benzimidazol-2-one | 2244737-98-0 | |
|
Brifentanyl | N-[(3R,4S)-1-[2-(4-Ethyl-5-oxotetrazol-1-yl)ethyl] -3-methylpiperidin-4-yl]-N-(2-fluorophenyl)-2-methoxyacetamide | 101345-71-5 | |
|
苄基卡芬太尼 | Methyl 1-benzyl-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate | 61085-72-1 | |
.png)
|
EAZ-91-05, Psicofentanil | (quinuclidin-3-yl) 4-[phenyl(propanoyl)amino]-1-[2-(indol-3-yl)ethyl]piperidine-4-carboxylate | ||
|
異芬太尼 | N-(1-Benzyl-3-methylpiperidin-4-yl)-N-phenylpropanamide | 79278-40-3 | |
|
Fentanyl azepane | N-phenyl-N-[1-(2-phenylethyl)azepan-4-yl]propanamide | ||
|
Furanylbenzylfentanyl | N-Phenyl-N-(1-benzylpiperidin-4-yl)furan-2-carboxamide | 497240-21-8 | |
|
Fentanyl 4-methylene analogue (WO 2007/093603) | N-phenyl-N-{[1-(2-phenylethyl)piperidin-4-yl]methyl}propanamide | 947139-57-3 | |
|
Indolylethylfentanyl | N-(1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl)-N-phenyl-propanamide | 58399-46-5 | |
|
IQMF-4[24] | N-[1-(2-Phenylethyl)piperidin-4-yl]-N-(1-phenylpyrazol-3-yl)prop-2-enamide | 497100-48-8 | |
|
Lofentanyl | methyl (3S,4R)-3-methyl-1-(2-phenylethyl)-4-[phenyl(propionyl)amino]piperidine-4-carboxylate | 61380-40-3 | |
|
N-Methylnorcarfentanyl | methyl 1-methyl-4-(N-phenylpropanamido)piperidine-4-carboxylate | 59708-50-8 | |
|
Meta-fluoro-methoxyacetylfentanyl | 2-Methoxy-N-(1-phenethylpiperidin-4-yl)-N-(3-fluorophenyl)acetamide | 2306825-32-9 | |
-pyrazolylethylfentanyl_structure.png)
|
4-(Methylthiazolyl)-pyrazolylethylfentanyl[25] | 1-[2-(1H-pyrazol-1-yl)ethyl]-4-(4-methylthiazol-2-yl)-4-(N-phenylpropionamido)piperidine | 120070-51-1 | |
|
Mirfentanyl | N-[1-(2-Phenylethyl)piperidin-4-yl]-N-pyrazin-2-yl-2-furamide | 117523-47-4 | |
|
奧芬太尼 | N-(2-Fluorophenyl)-2-methoxy-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide | 101343-69-5 | |
|
羥甲芬太尼 | N-[1-(2-hydroxy-2-phenylethyl)-3-methylpiperidin-4-yl]-N-phenylpropanamide | 78995-14-9 | |
|
羥甲卡芬太尼 | methyl 1-(2-hydroxy-2-phenylethyl)-3-methyl-4-(N-propanoylanilino)piperidine-4-carboxylate | ||
|
4"-Fluoroohmefentanyl | methyl 1-[2-hydroxy-2-(4-fluorophenyl)ethyl]-3-methyl-4-(N-propanoylanilino)piperidine-4-carboxylate | ||
|
4"-Fluoro-ohlofentanyl | methyl 1‐[2‐(4‐fluorophenyl)‐2‐hydroxyethyl]‐3‐methyl‐4‐(N‐phenylpropanamido)piperidine‐4‐carboxylate | ||
|
Orthofluorofentanyl | N-(2-Fluorophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide | 910616-29-4 | |
|
p-Bromofentanyl | N-(4-bromophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide | 117994-23-7 | |
|
p-Nitrofentanyl [26] | N-(4-Nitrophenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide | ||
|
Parafluoroisobutyrylbenzylfentanyl | N-[(1-benzylpiperidin-4-yl)methyl]-N-(4-fluorophenyl)-2-methylpropanamide | ||
|
4-Fluorocyclopropylbenzylfentanyl | N-(1-benzylpiperidin-4-yl)-N-(4-fluorophenyl)cyclopropanecarboxamide | 2344231-47-4 | |
|
Pivaloylfentanyl | 2,2-dimethyl-N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide | ||
|
Pyrrole-fentanyl [27] | N-[1-(2-Phenylethyl)piperidin-4-yl]-N-pyrrol-1-ylpropanamide | ||
|
R-30490 | N-[4-(Methoxymethyl)-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide | 60618-49-7 | |
|
瑞芬太尼 | methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate | 132875-61-7 | |
|
Remifentanil bis ethyl ester | ethyl 1-(3-ethoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate | ||
|
RR49 [28] | N1-[2-Fluoro-2-(2-fluorophenyl)ethyl]piperidin-4-ylN-phenylpropanamide | 2376328-79-7 | |
|
SR-16412 [29] | 1-(1-benzylpiperidin-4-yl)-3H-indol-2-one | 16223-24-8 | |
|
開環芬太尼[30] | N-phenyl-N-{4-[methyl(2-phenylethyl)amino]butan-2-yl}propanamide | 253342-66-4 | |
|
舒芬太尼（英語：sufentanil） | N-[4-(Methoxymethyl)-1-(2-thiofuran-2-ylethyl)-4-piperidyl]-N-phenylpropanamide | 56030-54-7 | |
|
Thiafentanil | methyl 4-(N-(2-methoxyacetyl)anilino)-1-(2-thiophen-2-ylethyl)piperidine-4-carboxylate | 101345-60-2 | |
|
Thiofentanyl | N-phenyl-N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}propanamide | 1165-22-6 | |
|
Trefentanyl | N1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl]-4-phenylpiperidin-4-ylN-(2-fluorophenyl)propanamide | 120656-93-1 | |
|
Trifluorofentanyl [31] | N-(3,4-difluorophenyl)-N-[1-(2-[4-fluorophenyl]ethyl)-4-piperidinyl]-propanamide | ||
|
Tropafentanyl (Fentanyl tropane) | N-phenyl-N-[8-(2-phenylethyl)-8-azabicyclo[3.2.1]octan-3-yl]propanamide | ||
|
3,4-dichloro-4''-methoxyfentanyl | N-(3,4-dichlorophenyl)-N-[1-(2-[4-methoxyphenyl]ethyl)-4-piperidinyl]-propanamide | 1161705-29-8 |
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