蛋白質c-Fos

人類蛋白質c-Fos是原癌基因，由FOS基因編碼，順序與病毒癌基因v-fos類似。c-Fos在大鼠纖維母細胞被FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus)轉化時第一次被發現。^[5]

FOS
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1A02、​1FOS、​1S9K
識別號
別名	FOS；, AP-1, C-p55, Fos proto-oncogene, AP-1 transcription factor subunit
外部ID	OMIM：164810 MGI：95574 HomoloGene：3844 GeneCards：FOS
基因位置（人類） 染色體 14號染色體[1] 基因座 14q24.3 起始 75,278,826 bp[1] 終止 75,282,230 bp[1]
基因位置（小鼠） 染色體 小鼠12號染色體[2] 基因座 12 D2|12 39.7 cM 起始 85,520,664 bp[2] 終止 85,524,047 bp[2]
RNA表現模式
查閱更多表現資料
基因本體 分子功能 • DNA結合 • sequence-specific DNA binding • R-SMAD binding • DNA結合轉錄因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 轉錄因子結合 • chromatin binding • 血漿蛋白結合 • protein heterodimerization activity • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific 細胞組分 • 細胞質 • 細胞質基質 • 膜 • 轉錄調節錯合物 • 核質 • 內質網 • neuron projection • 細胞核 • protein-DNA complex • transcription factor AP-1 complex 生物學過程 • cellular response to extracellular stimulus • response to muscle stretch • response to immobilization stress • cellular response to calcium ion • response to cytokine • regulation of transcription, DNA-templated • SMAD protein signal transduction • response to organic cyclic compound • response to light stimulus • regulation of transcription by RNA polymerase II • response to progesterone • female pregnancy • response to corticosterone • response to mechanical stimulus • 老化 • positive regulation of osteoclast differentiation • transcription by RNA polymerase II • 神經系統的發育 • cellular response to reactive oxygen species • response to gravity • Fc-epsilon receptor signaling pathway • positive regulation of transcription, DNA-templated • DNA甲基化 • response to lipopolysaccharide • 睡眠 • cellular response to hormone stimulus • regulation of DNA-binding transcription factor activity • 味覺厭惡 • skeletal muscle cell differentiation • response to cold • response to cAMP • inflammatory response • transforming growth factor beta receptor signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • response to toxic substance • positive regulation of transcription by RNA polymerase II • 基因調節 • cytokine-mediated signaling pathway • cellular response to cadmium ion • positive regulation of neuron death Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	2353	14281
Ensembl	ENSG00000170345	ENSMUSG00000021250
UniProt	P01100 Q6FG41	P01101
mRNA​序列	NM_005252	NM_010234
蛋白序列	NP_005243 NP_005243.1	NP_034364
基因位置​（UCSC）	Chr 14: 75.28 – 75.28 Mb	Chr 12: 85.52 – 85.52 Mb
PubMed​查找	[3]	[4]
維基資料
檢視/編輯人類 檢視/編輯小鼠