FOXP3

FOXP3（Forkhead box protein P3）基因，即叉頭框P3基因，也稱為scurfin蛋白，位於X染色體，屬於FOX蛋白家族，是一種與免疫系統響應有關的轉錄因子^[6]。

FOXP3
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 3QRF、​4WK8
識別號
別名	FOXP3；, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
外部ID	OMIM：300292 MGI：1891436 HomoloGene：8516 GeneCards：FOXP3
相關疾病
IPEX症候群[1]
基因位置（人類） 染色體 X染色體[2] 基因座 Xp11.23 起始 49,250,438 bp[2] 終止 49,270,477 bp[2]
基因位置（小鼠） 染色體 小鼠X染色體[3] 基因座 X A1.1|X 3.41 cM 起始 7,439,883 bp[3] 終止 7,461,484 bp[3]
RNA表現模式
查閱更多表現資料
基因本體 分子功能 • sequence-specific DNA binding • NF-kappaB binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • 血漿蛋白結合 • histone deacetylase binding • DNA結合轉錄因子活性 • NFAT protein binding • histone acetyltransferase binding • 金屬離子結合 • DNA結合 • protein homodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding 細胞組分 • 細胞核 • 胞內 • 細胞質 • 核質 • 大分子複合體 生物學過程 • negative regulation of cell population proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription by RNA polymerase II • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • 腫瘤壞死因子產生的負調控 • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T細胞活化 • positive regulation of immature T cell proliferation in thymus • positive regulation of regulatory T cell differentiation • negative regulation of transcription by RNA polymerase II • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • 染色體重建 • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression • anatomical structure morphogenesis • regulation of Wnt signaling pathway • regulation of regulatory T cell differentiation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	50943	20371
Ensembl	ENSG00000049768	ENSMUSG00000039521
UniProt	Q9BZS1	Q99JB6
mRNA​序列	NM_001114377 ​NM_014009	NM_001199347 ​NM_001199348 ​NM_054039
蛋白序列	NP_001107849 ​NP_054728	NP_001186276 ​NP_001186277 ​NP_473380
基因位置​（UCSC）	Chr X: 49.25 – 49.27 Mb	Chr X: 7.44 – 7.46 Mb
PubMed​查找	[4]	[5]
維基資料
檢視/編輯人類 檢視/編輯小鼠