HMOX1

血紅素加氧酶1（英語：heme oxygenase 1，縮寫HMOX1或HO-1）是一種血紅素加氧酶（EC 1.14.99.3），是血紅素代謝過程中的重要酶，它將血紅素轉化為膽綠素。

Heme oxygenase (decycling) 1 血紅素加氧酶1（脫環）
PDB rendering based on 1n3u.
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1N3U​, 1N45​, 1NI6​, 1OYK​, 1OYL​, 1OZE​, 1OZL​, 1OZR​, 1OZW​, 1S13​, 1S8C​, 1T5P​, 1TWN​, 1TWR​, 1XJZ​, 1XK0​, 1XK1​, 1XK2​, 1XK3​, 3CZY​, 3HOK​, 3K4F​, 3TGM​
標識
代號	HMOX1; HMOX1D; HO-1; HSP32; bK286B10
擴展標識	遺傳學：141250 鼠基因：96163 同源基因：31075 ChEMBL: 2823 GeneCards: HMOX1 Gene
EC編號	1.14.99.3
基因本體論描述 分子功能 · heme oxygenase (decyclizing) activity · phospholipase D activity · signal transducer activity · enzyme binding · heme binding · protein homodimerization activity · metal ion binding 細胞成分 · extracellular space · nucleus · nucleolus · endoplasmic reticulum · endoplasmic reticulum membrane · cytosol · caveola · membrane 生物過程 · angiogenesis · endothelial cell proliferation · wound healing involved in inflammatory response · negative regulation of leukocyte migration · porphyrin-containing compound metabolic process · heme oxidation · cellular iron ion homeostasis · response to oxidative stress · intracellular protein kinase cascade · small GTPase mediated signal transduction · excretion · regulation of blood pressure · cell death · intrinsic apoptotic signaling pathway in response to DNA damage · smooth muscle hyperplasia · cellular response to nutrient · negative regulation of mast cell cytokine production · erythrocyte homeostasis · low-density lipoprotein particle clearance · response to nicotine · heme catabolic process · response to hydrogen peroxide · negative regulation of apoptotic process · positive regulation of I-kappaB kinase/NF-kappaB cascade · negative regulation of mast cell degranulation · negative regulation of DNA binding · negative regulation of sequence-specific DNA binding transcription factor activity · negative regulation of neuron apoptotic process · regulation of transcription from RNA polymerase II promoter in response to oxidative stress · response to estrogen stimulus · small molecule metabolic process · positive regulation of chemokine biosynthetic process · regulation of angiogenesis · positive regulation of angiogenesis · positive regulation of vasodilation · positive regulation of smooth muscle cell proliferation · negative regulation of smooth muscle cell proliferation · regulation of sequence-specific DNA binding transcription factor activity · protein homooligomerization · iron ion homeostasis · transmembrane transport · cellular response to cadmium ion · cellular response to hypoxia Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	3162	15368
Ensembl	ENSG00000100292	ENSMUSG00000005413
UniProt	P09601	P14901
mRNA序列	NM_002133	NM_010442
蛋白序列	NP_002124	NP_034572
基因位置	Chr 22: 35.78 – 35.79 Mb	Chr 8: 75.09 – 75.1 Mb
PubMed查詢	[1]	[2]
閱 論 編

另見

• HMOX2

參考文獻

延伸閱讀

• Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999, 103 (1): 129–35. PMC 407858 . PMID 9884342. doi:10.1172/JCI4165.
• Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.. Brain. 2007, 130 (6): 1643–52. PMC 2291147 . PMID 17525142. doi:10.1093/brain/awm095.
• Soares MP, Brouard S, Smith RN, Bach FH. Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. Immunol. Rev. 2002, 184: 275–85. PMID 12086318. doi:10.1034/j.1600-065x.2001.1840124.x.
• Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 2002, 27 (1): 8–16. PMID 12091240. doi:10.1165/ajrcmb.27.1.4862.
• Buelow R, Tullius SG, Volk HD. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2002, 1 (4): 313–5. PMID 12099373. doi:10.1034/j.1600-6143.2001.10404.x.
• Ishikawa K. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Curr. Pharm. Des. 2003, 9 (30): 2489–97. PMID 14529548. doi:10.2174/1381612033453767.
• Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic. Biol. Med. 2005, 37 (8): 1097–104. PMID 15451051. doi:10.1016/j.freeradbiomed.2004.07.008.
• Ozono R. New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway. Current pharmaceutical biotechnology. 2006, 7 (2): 87–93. PMID 16724942. doi:10.2174/138920106776597630.
• Tracz MJ, Alam J, Nath KA. Physiology and pathophysiology of heme: implications for kidney disease. J. Am. Soc. Nephrol. 2007, 18 (2): 414–20. PMID 17229906. doi:10.1681/ASN.2006080894.
• Hill-Kapturczak N, Agarwal A. Haem oxygenase-1--a culprit in vascular and renal damage?. Nephrol. Dial. Transplant. 2007, 22 (6): 1495–9. PMID 17389623. doi:10.1093/ndt/gfm093.