STAT1

STAT1是轉錄因子中訊息傳遞及轉錄活化蛋白（STAT蛋白）家族的一員。

STAT1
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 3WWT、​1BF5、​1YVL、​2KA6
識別號
別名	STAT1；, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部ID	OMIM：600555 MGI：103063 HomoloGene：21428 GeneCards：STAT1
相關疾病
慢性黏膜皮膚念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置（人類） 染色體 2號染色體[2] 基因座 2q32.2 起始 190,908,460 bp[2] 終止 191,020,960 bp[2]
基因位置（小鼠） 染色體 小鼠1號染色體[3] 基因座 1 C1.1|1 26.81 cM 起始 52,158,599 bp[3] 終止 52,201,024 bp[3]
RNA表現模式
查閱更多表現資料
基因本體 分子功能 • DNA結合 • protein homodimerization activity • DNA結合轉錄因子活性 • RNA polymerase II general transcription initiation factor activity • signal transducer activity • RNA polymerase II cis-regulatory region sequence-specific DNA binding • 血漿蛋白結合 • 相同蛋白質結合 • 酶結合 • tumor necrosis factor receptor binding • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • cadherin binding • histone acetyltransferase binding • histone binding • ubiquitin-like protein ligase binding • promoter-specific chromatin binding • sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • CCR5 chemokine receptor binding • protein phosphatase 2A binding • DNA-binding transcription activator activity, RNA polymerase II-specific 細胞組分 • 細胞質 • 核質 • 核仁 • 細胞質的核周區域 • 細胞核 • 細胞質基質 • 軸突 • 樹突 • 大分子複合體 生物學過程 • regulation of apoptotic process • metanephric mesenchymal cell proliferation involved in metanephros development • regulation of transcription, DNA-templated • cellular response to interferon-beta • regulation of transcription by RNA polymerase II • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • tumor necrosis factor-mediated signaling pathway • negative regulation of transcription by RNA polymerase II • renal tubule development • response to interferon-beta • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of endothelial cell proliferation • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • positive regulation of mesenchymal cell proliferation • negative regulation of metanephric nephron tubule epithelial cell differentiation • negative regulation of angiogenesis • negative regulation by virus of viral protein levels in host cell • viral process • endothelial cell migration • positive regulation of transcription by RNA polymerase II • 訊息傳遞 • macrophage derived foam cell differentiation • positive regulation of erythrocyte differentiation • type I interferon signaling pathway • cellular response to interferon-gamma • positive regulation of defense response to virus by host • positive regulation of interferon-alpha production • positive regulation of transcription, DNA-templated • defense response to virus • interferon-gamma-mediated signaling pathway • receptor signaling pathway via JAK-STAT • response to nutrient • blood circulation • positive regulation of cell population proliferation • response to mechanical stimulus • response to organic cyclic compound • cellular response to insulin stimulus • response to cytokine • response to hydrogen peroxide • response to peptide hormone • positive regulation of smooth muscle cell proliferation • response to cAMP • positive regulation of nitric-oxide synthase biosynthetic process • cellular response to cytokine stimulus • cellular response to organic cyclic compound • positive regulation of transcription of Notch receptor target • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • interleukin-6-mediated signaling pathway • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway • interleukin-9-mediated signaling pathway • defense response • regulation of cell population proliferation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	6772	20846
Ensembl	ENSG00000115415	ENSMUSG00000026104
UniProt	P42224	P42225
mRNA​序列	​NM_007315 ​NM_139266	NM_001205313 ​NM_001205314 ​NM_009283 ​NM_001357627
蛋白序列	NP_009330 ​NP_644671	無資料
基因位置​（UCSC）	Chr 2: 190.91 – 191.02 Mb	Chr 1: 52.16 – 52.2 Mb
PubMed​查找	[4]	[5]
維基資料
檢視/編輯人類 檢視/編輯小鼠

STAT1涉及I型、II型或III型干擾素活化基因的正調控。在干擾素-γ刺激下，STAT1會組成同源二聚體或與STAT3組成異二聚體結合到GAS（Interferon-Gamma-Activated Sequence，干擾素γ活化序列）啟動子上；而在干擾素-α或干擾素-β刺激下，STAT1會與STAT2組成異二聚體結合到ISRE（Interferon-Stimulated Response Element，干擾素活化反應元件）啟動子上^[6]。在這兩種情況下，STAT二聚體與啟動子的結合都會導致ISG（Interferon-Stimulated Genes，干擾素活化基因）的表現。

STAT1可由二烯丙基二硫誘導表現^[7]

相互作用

STAT1能與下列蛋白質發生相互作用：

• 蛋白激酶R（英語：Protein kinase R）^[8][9]
• Src^[10][11]
• IRF1^[12]
• STAT3^[13][14][15]
• MCM5^[16][17]
• STAT2^[18][19][20]
• CD117^[21]
• Fanconi anemia, complementation group C^[22][23][24]
• CREB結合蛋白（英語：CREB-binding protein）^[25]
• 白介素27受體α亞基（英語：Interleukin 27 receptor, alpha subunit）^[26]
• PIAS1^[27]
• BRCA1^[28]
• 表皮生長因子受體^[10][15]
• PTK2^[29]
• Mammalian target of rapamycin^[30]
• IFNAR2^[31][32]
• PRKCD^[30]
• TRADD^[33]
• C-jun^[34]
• Calcitriol receptor^[35]
• ISGF3G^[36]
• GNB2L1^[32][37]