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有名的16位元處理器包含Intel 808680286摩托罗拉68000和WDC 65C816。


16位元應用程式是任何的MS-DOS或早期版本的微軟Windows的軟體,原先可以在16位元Intel 8088Intel 80286微處理器上執行。這些應用程式使用20位元區段-偏移位址表示法來擴充,只有用在16位元處理器中可定址記憶體的範圍。包含大於 KB指令的程式和資料因此必須由特別的副程式,在他們的64KB節區之間切換,增加了16位元應用程式的複雜度。



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