CXCL10

CXCL10
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1O80、1LV9、1O7Y、1O7Z
識別號
别名	CXCL10；, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
外部ID	OMIM：147310 MGI：1352450 HomoloGene：1203 GeneCards：CXCL10
基因位置（人类）
染色体	4號染色體
终止	76,023,497 bp
基因位置（小鼠）
染色体	小鼠5号染色体
终止	92,496,748 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 細胞因子活性; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • 血浆蛋白结合; • cAMP-dependent protein kinase regulator activity; • signaling receptor binding; • chemoattractant activity;
細胞組分	• 細胞外區域; • external side of plasma membrane; • 細胞外空間; • 胞內;
生物學過程	• regulation of endothelial tube morphogenesis; • negative regulation of myoblast differentiation; • cellular response to heat; • response to vitamin D; • positive regulation of cell migration; • T cell chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • response to virus; • muscle organ development; • positive regulation of monocyte chemotaxis; • positive regulation of release of sequestered calcium ion into cytosol; • endothelial cell activation; • positive regulation of cAMP-mediated signaling; • regulation of T cell chemotaxis; • blood circulation; • 趨化性; • positive regulation of leukocyte chemotaxis; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • negative regulation of myoblast fusion; • defense response to virus; • regulation of cell population proliferation; • 免疫反应; • positive regulation of cell population proliferation; • response to auditory stimulus; • negative regulation of angiogenesis; • response to cold; • cellular response to lipopolysaccharide; • response to gamma radiation; • positive regulation of T cell migration; • 訊息傳遞; • positive regulation of transcription by RNA polymerase II; • regulation of protein kinase activity; • defense response; • inflammatory response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • response to bacterium; • neutrophil chemotaxis; • leukocyte chemotaxis; • positive chemotaxis; • regulation of apoptotic process;
	Sources:Amigo / QuickGO
直系同源
	3627
	15945
	ENSG00000169245
	ENSMUSG00000034855
	P02778
	P17515
	NM_001565
	NM_021274
	NP_001556
	NP_067249
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CXCL10（英語：C-X-C motif chemokine 10）是一小分子的细胞因子属于CXC趋化因子家族^[5]，又被称作“干扰素伽玛诱导的10千道尔顿蛋白”（10 kDa interferon-gamma-induced protein，IP-10）^[6] 。干扰素伽玛可以在多种细胞（如巨噬细胞^[7] ，单核细胞^[7] ，内皮细胞^[8]和成纤维细胞）中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用^[9]^[10]，促进T细胞黏附于内皮细胞^[8]，抗肿瘤^[11]，及血管新生^[8]。人类的CXCL10基因与CXCL9，CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体 CXCR3而起其细胞趋化作用^[9]^[10] 。

事实速览 CXCL10, 已知的結構 ...

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CXCL10

参见

参考文献

外部链接

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