APOA5
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11.[5][6][7] It is significantly expressed in liver.[8] The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.[9] Considering its association with lipoprotein levels, APOA5 is implicated in metabolic syndrome.[10] The APOA5 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.[11]