Andexanet alfa
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Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding.[8] It has not been found to be useful for other factor Xa inhibitors.[9] It is given by injection into a vein.[9]
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Trade names | Andexxa, Ondexxya, others |
Other names | Coagulation factor Xa (recombinant), inactivated-zhzo, PRT06445, r-Antidote, PRT4445 |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous injection |
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Elimination half-life | 5 h to 7 h |
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Common side effects include pneumonia and urinary tract infections.[9] Severe side effects may include blood clots, heart attacks, strokes, or cardiac arrest.[9] It works by binding to rivaroxaban and apixaban.[9]
It was approved for medical use in the United States in May 2018.[8] It was developed by Portola Pharmaceuticals.[10]