Aripiprazole
Atypical antipsychotic / From Wikipedia, the free encyclopedia
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Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic.[7] It is primarily used in the treatment of schizophrenia and bipolar disorder;[7] other uses include as an add-on treatment in major depressive disorder and obsessive compulsive disorder (OCD), tic disorders, and irritability associated with autism.[7] Aripiprazole is taken by mouth or via injection into a muscle.[7] A Cochrane review found low-quality evidence of effectiveness in treating schizophrenia.[8]
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Pronunciation | /ˌɛərɪˈpɪprəzoʊl/ AIR-ih-PIP-rə-zohl Abilify /əˈbɪlɪfaɪ/ ə-BIL-if-eye |
Trade names | Abilify, Aristada, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603012 |
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Routes of administration | By mouth, intramuscular |
Drug class | Atypical antipsychotic |
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Bioavailability | 87%[4][5][6] |
Protein binding | >99%[4][5][6] |
Metabolism | Liver (mostly via CYP3A4 and 2D6[4][5][6]) |
Elimination half-life | 75 hours (active metabolite is 94 hours)[4][5][6] |
Excretion | Kidney (27%; <1% unchanged) feces (60%; 18% unchanged)[4][5][6] |
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ECHA InfoCard | 100.112.532 |
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Formula | C23H27Cl2N3O2 |
Molar mass | 448.39 g·mol−1 |
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In adults, side effects with greater than 10% incidence include weight gain, headache, akathisia, insomnia, and gastrointestinal effects like nausea and constipation, and lightheadedness and twitching which is common in antidepressants and antipsychotics.[4][5][6][9][10] Side effects in children are similar, and include sleepiness, increased appetite, and stuffy nose.[9] Common side effects include vomiting, constipation, sleepiness, dizziness, weight gain and movement disorders.[7] Serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia and anaphylaxis.[7] It is not recommended for older people with dementia-related psychosis due to an increased risk of death.[7] In pregnancy, there is evidence of possible harm to the fetus.[7][11] It is not recommended in women who are breastfeeding.[7] It has not been very well studied in people less than 18 years old.[7]
Aripiprazole was approved for medical use in the United States in 2002.[7] It is available as a generic medication.[12] In 2021, it was the 99th most commonly prescribed medication in the United States, with more than 6 million prescriptions.[13][14] It is on the World Health Organization's List of Essential Medicines.[15]