Clonal deletion
Removal of autoreactive B and T cells before they become immunocompetent / From Wikipedia, the free encyclopedia
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In immunology, clonal deletion is the removal through apoptosis of B cells and T cells that have expressed receptors for self before developing into fully immunocompetent lymphocytes.[1][2] This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance. Central tolerance prevents B and T lymphocytes from reacting to self. Thus, clonal deletion can help protect individuals against autoimmunity. Clonal deletion is thought to be the most common type of negative selection.[1] It is one method of immune tolerance.