Dihydroorotate dehydrogenase
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Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane (IMM).[1] Inhibitors of this enzyme are used to treat autoimmune diseases such as rheumatoid arthritis.[2]
See also: Dihydroorotate dehydrogenase (quinone)
Quick Facts Identifiers, EC no. ...
Dihydroorotate oxidase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.5.2 | ||||||||
CAS no. | 9029-03-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
Identifiers | |||||||||
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Symbol | DHO_dh | ||||||||
Pfam | PF01180 | ||||||||
InterPro | IPR001295 | ||||||||
PROSITE | PDOC00708 | ||||||||
SCOP2 | 1dor / SCOPe / SUPFAM | ||||||||
OPM superfamily | 56 | ||||||||
OPM protein | 1uum | ||||||||
CDD | cd02810 | ||||||||
Membranome | 250 | ||||||||
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Quick Facts Human dihydroorotate dehydrogenase, Identifiers ...
Human dihydroorotate dehydrogenase | |||||||
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Identifiers | |||||||
Symbol | DHODH | ||||||
NCBI gene | 1723 | ||||||
HGNC | 2867 | ||||||
OMIM | 126064 | ||||||
PDB | 1D3G | ||||||
RefSeq | NM_001361 | ||||||
UniProt | Q02127 | ||||||
Other data | |||||||
EC number | 1.3.3.1 | ||||||
Locus | Chr. 16 q22 | ||||||
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