Factor XIII
Class of enzymes / From Wikipedia, the free encyclopedia
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Factor XIII or fibrin stabilizing factor is a zymogen found in blood of humans and some other animals. It is activated by thrombin to factor XIIIa. Factor XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency.[1]
Quick Facts coagulation factor XIII,A1 polypeptide, Identifiers ...
coagulation factor XIII, A1 polypeptide | |||||||
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Identifiers | |||||||
Symbol | F13A1 | ||||||
Alt. symbols | F13A | ||||||
NCBI gene | 2162 | ||||||
HGNC | 3531 | ||||||
OMIM | 134570 | ||||||
RefSeq | NM_000129 | ||||||
UniProt | P00488 | ||||||
Other data | |||||||
EC number | 2.3.2.13 | ||||||
Locus | Chr. 6 p24.2-p23 | ||||||
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Quick Facts coagulation factor XIII,B polypeptide, Identifiers ...
coagulation factor XIII, B polypeptide | |||||||
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Identifiers | |||||||
Symbol | F13B | ||||||
NCBI gene | 2165 | ||||||
HGNC | 3534 | ||||||
OMIM | 134580 | ||||||
RefSeq | NM_001994 | ||||||
UniProt | P05160 | ||||||
Other data | |||||||
Locus | Chr. 1 q31-q32.1 | ||||||
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Human XIII is a heterotetramer. It consists of 2 enzymatic A peptides and 2 non-enzymatic B peptides. XIIIa is a dimer of activated A peptides.[1]