GABAB receptor
G-protein coupled receptor / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about GABAB receptor?
Summarize this article for a 10 year old
GABAB receptors (GABABR) are G-protein coupled receptors for gamma-aminobutyric acid (GABA), therefore making them metabotropic receptors, that are linked via G-proteins to potassium channels.[1] The changing potassium concentrations hyperpolarize the cell at the end of an action potential. The reversal potential of the GABAB-mediated IPSP (inhibitory postsynaptic potential) is −100 mV, which is much more hyperpolarized than the GABAA IPSP. GABAB receptors are found in the central nervous system and the autonomic division of the peripheral nervous system.[2]
gamma-aminobutyric acid (GABA) B receptor, 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | GABBR1 | ||||||
NCBI gene | 2550 | ||||||
HGNC | 4070 | ||||||
OMIM | 603540 | ||||||
RefSeq | NM_021905 | ||||||
UniProt | Q9UBS5 | ||||||
Other data | |||||||
Locus | Chr. 6 p21.3 | ||||||
|
gamma-aminobutyric acid (GABA) B receptor, 2 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | GABBR2 | ||||||
Alt. symbols | GPR51 | ||||||
NCBI gene | 9568 | ||||||
HGNC | 4507 | ||||||
OMIM | 607340 | ||||||
RefSeq | NM_005458 | ||||||
UniProt | O75899 | ||||||
Other data | |||||||
Locus | Chr. 9 q22.1-22.3 | ||||||
|
The receptors were first named in 1981 when their distribution in the CNS was determined, which was determined by Norman Bowery and his team using radioactively labelled baclofen.[3]