Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene.[5][6][7]
Quick Facts SLC37A4, Identifiers ...
SLC37A4 |
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Identifiers |
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Aliases | SLC37A4, G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG-19, TRG19, PRO0685, solute carrier family 37 member 4, CDG2W |
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External IDs | OMIM: 602671; MGI: 1316650; HomoloGene: 37482; GeneCards: SLC37A4; OMA:SLC37A4 - orthologs |
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Wikidata |
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It consists of three subunits, each of which are vital components of the multi-enzyme Glucose-6-Phosphatase Complex (G6Pase). This important enzyme complex is located within the membrane of the endoplasmic reticulum, and catalyzes the terminal reactions in both glycogenolysis and gluconeogenesis.[8] The G6Pase complex is most abundant in liver tissue, but also present in kidney cells, small intestine, pancreatic islets and at a lower concentration in the gallbladder.[9][10] The G6Pase complex is highly involved in the regulation of homeostasis and blood glucose levels. Within this framework of glucose regulation, the translocase components are responsible for transporting the substrates and products across the endoplasmic reticulum membrane, resulting in the release of free glucose into the bloodstream.[8]