Hemojuvelin (HJV), also known as repulsive guidance molecule C (RGMc) or hemochromatosis type 2 protein (HFE2), is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis in humans, a severe form of hemochromatosis. In humans, the hemojuvelin protein is encoded by the HFE2 gene.[5][6] Hemojuvelin is a member of the repulsive guidance molecule family of proteins.[7][8] Both RGMa and RGMb are found in the nervous system,[9][10] while hemojuvelin is found in skeletal muscle and the liver.[10][11]
Quick Facts HJV, Available structures ...
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