Indometacin
Anti-inflammatory drug / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Indometacin?
Summarize this article for a 10 year old
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.[2][3]
Clinical data | |
---|---|
Pronunciation | /ɪndoʊˈmɛtəsɪn/ |
Trade names | Indocid, Indocin |
Other names | Indomethacin (USAN US) |
AHFS/Drugs.com | Monograph |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth, rectal, intravenous, topical |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | ~100% (oral), 80–90% (rectal) |
Protein binding | 99%[2] |
Metabolism | Liver |
Elimination half-life | 2.6-11.2 hours (adults), 12-28 hours (infants)[2] |
Excretion | Kidney (60%), fecal (33%) |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL |
|
PDB ligand | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.170 |
Chemical and physical data | |
Formula | C19H16ClNO4 |
Molar mass | 357.79 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
It was patented in 1961 and approved for medical use in 1963.[4][5] It is on the World Health Organization's List of Essential Medicines.[6] In 2021, it was the 253rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.[7][8]