Nalorphine
Chemical compound / From Wikipedia, the free encyclopedia
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Nalorphine (INNTooltip International Nonproprietary Name) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist–antagonist with opioid antagonist and analgesic properties.[2] It was introduced in 1954[3] and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence.[4]
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Trade names | Lethidrone, Nalline |
Other names | N-Allylnormorphine |
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ECHA InfoCard | 100.000.497 |
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Formula | C19H21NO3 |
Molar mass | 311.381 g·mol−1 |
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Nalorphine was the second opioid antagonist to be introduced, preceded by nalodeine (N-allylnorcodeine) in 1915 and followed by naloxone in 1960 and naltrexone in 1963.[3] Due to potent activation of the κ-opioid receptor, nalorphine produces side effects such as dysphoria, anxiety, confusion, and hallucinations, and for this reason, is no longer used medically.[2][3][5]