Promyelocytic leukemia protein
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19[5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin[5] of the cell nucleus. These nuclear bodies are present in mammalian nuclei, at about 1 to 30 per cell nucleus.[5] PML-NBs are known to have a number of regulatory cellular functions, including involvement in programmed cell death, genome stability, antiviral effects and controlling cell division.[5][6] PML mutation or loss, and the subsequent dysregulation of these processes, has been implicated in a variety of cancers.[5]