Protein Z
Mammalian protein involved in blood clotting / From Wikipedia, the free encyclopedia
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For other uses, see Z-gene (disambiguation).
Protein Z (PZ or PROZ) is a mammalian protein which is encoded by the PROZ gene.[2][3]
Quick Facts Identifiers, Symbol ...
protein Z | |||||||
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Identifiers | |||||||
Symbol | PROZ | ||||||
NCBI gene | 8858 | ||||||
HGNC | 9460 | ||||||
OMIM | 176895 | ||||||
PDB | 3F1s | ||||||
RefSeq | NM_003891 | ||||||
UniProt | P22891 | ||||||
Other data | |||||||
Locus | Chr. 13 q34 | ||||||
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Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is a glycoprotein. Protein Z functions to inhibit blood coagulation by binding to an inhibitor.[4] It is a GLA domain protein and thus Vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.