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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.[5][6][7]
RAPGEF2 is a cyclic AMP binding protein.[8][9]
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs) such as RAPGEF2 serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.[6]
RAPGEF2 has been shown to interact with RAP1A[6] and RALGDS.[10]
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